Document Detail


Sensorineural hearing loss alters recovery from short-term adaptation in the C57BL/6 mouse.
MedLine Citation:
PMID:  8575994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several strains of laboratory mouse (Mus musculus) have a pattern of hearing loss which resembles that found in humans. The C57BL/6 strain of mouse has a genetic defect that results in degeneration of the organ of Corti, originating in the basal, high-frequency region and then proceeding apically over time. The end result is a severe-to-profound sensorineural hearing loss (SNHL) by 14 months of age. In contrast, auditory function of the CBA strain remains normal through its early life span then slowly declines later in life, much like that typified by human presbycusis. The purpose of the present study was to compare ABR (peak 5) forward masking recovery functions in young, normal-hearing CBA and C57BL/6 mice to hearing-impaired C57BL/6 mice. ABR audiograms were obtained prior to collecting the tone-on-tone forward masking data. Masking was defined as a 50% reduction in the P5 component of the ABR, elicited and masked by 12 kHz tone bursts, using masker/probe time delays from 0 to 100 ms. Time constants were computed from an exponential model fit to the recovery functions (masker level vs. time delay). In hearing-impaired animals there was a significant increase in recovery from short-term adaptation as measured by the time constants, as well as a significant latency shift in the P5 component. The effects of SNHL on the recovery of the P5 component from short-term adaptation was comparable to that reported behaviorally for human hearing-impaired listeners and physiologically from the inferior colliculus (IC) of chinchillas suffering permanent threshold shifts.
Authors:
J P Walton; R D Frisina; L R Meierhans
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  88     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-03-14     Completed Date:  1996-03-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  19-26     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Rochester School of Medicine and Dentistry, NY 14642-8629, USA.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation*
Animals
Audiometry
Auditory Cortex / physiology
Auditory Threshold / physiology*
Disease Models, Animal
Hearing Loss, Sensorineural / congenital,  genetics,  physiopathology*
Mice
Mice, Inbred C57BL / physiology*
Mice, Inbred CBA / physiology*
Organ of Corti / pathology
Perceptual Masking / physiology*
Presbycusis / physiopathology
Species Specificity
Grant Support
ID/Acronym/Agency:
P01 AG 09524/AG/NIA NIH HHS; R29 DC00408/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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