Document Detail


Sensorimotor impairment and elevated levels of dopamine metabolites in the neostriatum occur rapidly after intranigral injection of 6-hydroxydopamine or gamma-hydroxybutyrate in awake rats.
MedLine Citation:
PMID:  6427648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The unilateral injection of 6-hydroxydopamine (8 micrograms) into the ventral tegmental area of awake rats produced a rapidly developing and irreversible sensory neglect to contralateral tactile stimuli. This neglect developed in a caudal to rostral direction on the affected body surface and coincided with significant elevation in the concentrations of dopamine and two of its metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the ipsilateral neostriatum. The unilateral injection of procaine or gamma-hydroxybutyric acid (GHB) into the substantia nigra of awake animals also produced a contralateral neglect that developed in a caudal to rostral direction, but the behavioral effect of these drugs diminished within 1 hr. Concentrations of dopamine, dihydroxyphenylacetic acid and homovanillic acid in the neostriatum were markedly elevated during continuous infusions of procaine or gamma-hydroxybutyric acid. The extent of sensory neglect and changes in dopamine metabolism in the neostriatum varied according to the amount of gamma-hydroxybutyric acid injected into the nigra and according to the proximity of injections of gamma-hydroxybutyric acid to the pars compacta. The rapid onset of sensory neglect following microinjections of 6-hydroxydopamine, procaine or gamma-hydroxybutyric acid is consistent with the ability of each of these drugs to block the conduction of impulses in mesostriatal neurons and suggests that concomitant increases in levels of dopamine, dihydroxyphenylacetic acid and homovanillic acid in the neostriatum resulted from decreases in the release of dopamine coupled with increased synthesis of dopamine. These findings also indicate that the catabolism of dopamine to dihydroxyphenylacetic acid or homovanillic acid may originate intraneuronally, without prior release of dopamine and its recapture by mesostriatal terminals, if the flow of impulses in this pathway has been blocked.
Authors:
C A Altar; S O'Neil; J F Marshall
Related Documents :
2999828 - Effects of gamma-linolenic acid, dihomo-gamma-linolenic acid and ethanol on cultured hu...
1749748 - Clonidine differentially modulates the release of endogenous gaba in various rat brain ...
3864158 - Photoaffinity labeling of diphtheria toxin fragment a with nad: structure of the photop...
2892118 - Effects of inhibition and modulation of gamma-glutamyltransferase on glutamine and glut...
16657798 - Inhibitory effect of carbohydrate on flowering in lemna perpusilla: iii. effects of res...
20162328 - Influence of unsaturated carbonic acids on hemocompatibility and cytotoxicity of poly-v...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuropharmacology     Volume:  23     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-07-12     Completed Date:  1984-07-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  309-18     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
4-Butyrolactone / administration & dosage,  pharmacology
Animals
Biotransformation
Corpus Striatum / metabolism*
Dopamine / metabolism*
Homovanillic Acid / metabolism
Hydroxybutyrates / pharmacology*
Hydroxydopamines / administration & dosage,  pharmacology*
Male
Microinjections
Oxidopamine
Procaine / administration & dosage
Psychomotor Performance / drug effects*
Rats
Rats, Inbred Strains
Sodium Oxybate / administration & dosage,  pharmacology*
Substantia Nigra / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
AG 00096/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Hydroxybutyrates; 0/Hydroxydopamines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 1199-18-4/Oxidopamine; 306-08-1/Homovanillic Acid; 502-85-2/Sodium Oxybate; 59-46-1/Procaine; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Age-related differences in the effect of castration upon hypothalamic LHRH content in male rats.
Next Document:  Inhibition by sodium valproate of the transport of GABA through the Deiters' neurone plasma membrane...