Document Detail

Sensorimotor adaptation error signals are derived from realistic predictions of movement outcomes.
MedLine Citation:
PMID:  21123665     Owner:  NLM     Status:  MEDLINE    
Neural systems that control movement maintain accuracy by adaptively altering motor commands in response to errors. It is often assumed that the error signal that drives adaptation is equivalent to the sensory error observed at the conclusion of a movement; for saccades, this is typically the visual (retinal) error. However, we instead propose that the adaptation error signal is derived as the difference between the observed visual error and a realistic prediction of movement outcome. Using a modified saccade-adaptation task in human subjects, we precisely controlled the amount of error experienced at the conclusion of a movement by back-stepping the target so that the saccade is hypometric (positive retinal error), but less hypometric than if the target had not moved (smaller retinal error than expected). This separates prediction error from both visual errors and motor corrections. Despite positive visual errors and forward-directed motor corrections, we found an adaptive decrease in saccade amplitudes, a finding that is well-explained by the employment of a prediction-based error signal. Furthermore, adaptive changes in movement size were linearly correlated to the disparity between the predicted and observed movement outcomes, in agreement with the forward-model hypothesis of motor learning, which states that adaptation error signals incorporate predictions of motor outcomes computed using a copy of the motor command (efference copy).
Aaron L Wong; Mark Shelhamer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-12-01
Journal Detail:
Title:  Journal of neurophysiology     Volume:  105     ISSN:  1522-1598     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-22     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1130-40     Citation Subset:  IM    
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MeSH Terms
Adaptation, Physiological / physiology*
Anticipation, Psychological / physiology*
Feedback, Sensory*
Motion Perception / physiology*
Saccades / physiology*
Task Performance and Analysis*
Young Adult
Grant Support
R21 EY019713/EY/NEI NIH HHS; R21-EY-019713/EY/NEI NIH HHS; T32-DC-000023/DC/NIDCD NIH HHS

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