| Sensitizing capacity of three methyl alkanesulphonates: a murine in vivo and in vitro model of allergic contact dermatitis. | |
| | |
MedLine Citation:
|
PMID: 1964034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A murine model for in vivo and in vitro studies of contact sensitization to methyl alkanesulphonate derivatives has been developed. Contact sensitivity was quantified in vivo by measuring the ear thickness increase, and the influence of the alkyl chain length (hexyl, dodecyl, hexadecyl) was investigated. Long chain methyl alkanesulphonates (dodecyl and hexadecyl) are strong sensitizers, while the shorter alkyl chain, methyl hexanesulphonate, is a weak sensitizer. In vitro lymphocyte blastogenesis was measured by the 3H-thymidine uptake and exhibited a stimulation index between 2 and 8. The results nicely parallelled the in vivo sensitization measurements, except for methyl dodecanesulphonate. This could be explained by the cytotoxic activity of this compound, the most toxic of the three methyl alkanesulphonates tested. Thus, murine sensitization to methyl alkanesulphonates provides a good model system for preliminary investigations of delayed type hypersensitivity mechanisms. |
| | |
Authors:
|
R Fraginals; J P Lepoittevin; C Benezra |
Related Documents
:
|
14974534 - Genetic parameters for calving difficulty, stillbirth, and birth weight for hereford an... 8813864 - Prevention of anaemia in inner city toddlers by an iron supplemented cows' milk formula. 19566584 - High intestinal iga associates with reduced risk of ige-associated allergic diseases. 8190524 - Human alpha-lactalbumin and bovine beta-lactoglobulin absorption in premature infants. 9396524 - A new diagnostic approach to biliary atresia with emphasis on the ultrasonographic tria... 19554214 - Rna detection and subtype c assessment of hiv-1 in infants with diarrhea in ethiopia. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Archives of dermatological research Volume: 282 ISSN: 0340-3696 ISO Abbreviation: Arch. Dermatol. Res. Publication Date: 1990 |
Date Detail:
|
Created Date: 1991-04-22 Completed Date: 1991-04-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8000462 Medline TA: Arch Dermatol Res Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 455-8 Citation Subset: IM |
Affiliation:
|
Laboratoire de Dermatochimie associé au CNRS, Université Louis Pasteur, CHU, Strasbourg, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkanesulfonates
/
adverse effects,
pharmacology* Animals Dermatitis, Contact / pathology* Disease Models, Animal Drug Hypersensitivity / pathology* Epidermis / drug effects, metabolism, pathology Female Lymphocyte Activation / drug effects Mice Mice, Inbred BALB C Thymidine / metabolism Tritium / diagnostic use |
| Chemical | |
Reg. No./Substance:
|
0/Alkanesulfonates; 10028-17-8/Tritium; 10307-26-3/methyl n-hexylsulfonate; 50-89-5/Thymidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Human papillomavirus DNA from warts for typing by endonuclease restriction patterns: purification by...
Next Document: Inhibitory guanine nucleotide binding protein in pig epidermis: regulation of epidermal adenylate cy...