Document Detail

Sensitizing capacity of 5,5'-di-tert-butyl-2,2'-dihydorxy-(hydroxymethyl)-dibenzyl ethers in the guinea pig.
MedLine Citation:
PMID:  10945744     Owner:  NLM     Status:  MEDLINE    
In patients hypersensitive to p-tert-butylphenol-formaldehyde resin (PTBP-F-R), it is for diagnostic, therapeutic and preventive reasons necessary to know the identity of the primary sensitizing substances, their sensitizing capacities as well as their cross-reaction patterns. We have recently shown that the 2 dimers in PTBP-F-R, 5,5'-di-tert-butyl-2,2'-dihydroxy-3-hydroxymethyl-dibenzyl ether (X) and 5,5'-di-tert-butyl-2,2'-dihydroxy-3,3'-dihydroxymethyl-dibenzyl ether (IX) are contact sensitizers in man. The aim of this study was to investigate the sensitizing capacities of these dimers in PTBP-F-R and potential cross-reacting substances in the guinea pig with the guinea pig maximization test. IX, X, 2,6-dimethylol-p-tert-butylphenol (2,6-MPTBP), 2-methylol-p-tert-butylphenol (2-MPTBP), p-tert-butylcatechol (PTBC), 5,5'-di-tert-butyl-2,2'-dihydroxy-dibenzyl ether (XI) were used as possible cross reacting substances. IX and X were shown to be sensitizers. When compared to the sensitizers in phenol-formaldehyde resin, IX is a strong sensitizer (p= 0.00052) and X a moderate sensitizer (p=0.0053). Animals sensitized to IX showed cross-reactions to X (p=0.010), 2,6-MPTBP (p=0.0011) and PTBC (p=0.0498). Animals sensitized to X showed no cross-reactions to the substances that were tested. The results indicate that IX is a main allergen in PTBP-F-R, with possibly also X.
E Zimerson; M Bruze
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  43     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-11-22     Completed Date:  2001-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  72-8     Citation Subset:  IM    
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Sweden.
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MeSH Terms
Allergens / adverse effects*,  chemistry
Chromatography, High Pressure Liquid
Cross Reactions
Dermatitis, Allergic Contact / etiology*
Guinea Pigs
Magnetic Resonance Spectroscopy
Mass Spectrometry
Phenyl Ethers / adverse effects*,  chemistry
Resins, Synthetic / adverse effects*,  chemistry
Reg. No./Substance:
0/Allergens; 0/Phenyl Ethers; 0/Resins, Synthetic; 103-50-4/dibenzyl ether; 25085-50-1/p-tert-butylphenolformaldehyde resin

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