| Sensitized central controller of ventilation in rats with chronic heart failure contributes to hyperpnea little at rest but more during exercise. | |
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MedLine Citation:
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PMID: 17946641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To understand the pathophysiologic basis of exercise hyperpnea in chronic heart failure (CHF), we have developed an experimental method quantitatively characterizing ventilatory regulation system in rats. An equilibrium diagram illustrates the characteristics of two subsystems, i.e., the central controller (arterial CO2 tension [Pa(CO2)] to minute ventilation [V(E)] relationship) and peripheral plant (V(E) to Pa(CO2) relationship). In this study, we compared these between normal and CHF rats at rest. METHOD: In anesthetized 6 postinfarction CHF rats and 6 normal rats, we induced hypercapnia by changing inspiratory CO2 fraction and measured the steady-state Pa(CO2) to V(E) relation. We altered V(E) by varying the level of artificial ventilation and measured the V(E) to Pa(CO2) relation. RESULTS: Central controller gain S was significantly lager in CHF rats, confirming clinical observation. The V(E) at rest (operating point) in CHF was 24% larger; central hypersensitivity, however, contributed little (6%) to this increase. CONCLUSION: Central hypersensitivity alone would not explain hyperpnea at rest in CHF rats. Considering the right and upward shift of V(E) to Pa(CO2) relation, central hypersensitivity contributes more to hyperpnea during exercise. The potential difference between normal and CHF rats in exercise-induced changes in controller and plant should be examined to fully understand the mechanism of exercise hyperpnea and to develop a method to attenuate this. |
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Authors:
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Tadayoshi Miyamoto; Masashi Inagaki; Hiroshi Takaki; Atsunori Kamiya; Toru Kawada; Toshiaki Shishido; Masaru Sugimachi; Kenji Sunagawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 1 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2006 |
Date Detail:
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Created Date: 2007-10-23 Completed Date: 2008-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 4627-30 Citation Subset: IM |
Affiliation:
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National Cardiovascular Center Res. Inst., Suita, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomedical Engineering / methods Equipment Design Exercise* Exercise Test Feedback Heart Failure / diagnosis*, therapy Humans Hyperventilation* Oxygen Consumption Pulmonary Ventilation* Rats Respiration Rest |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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