| Sensitization of tumor cells by targeting histone deacetylases. | |
| | |
MedLine Citation:
|
PMID: 22120677 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Epigenetic mechanisms may contribute to drug resistance by interfering with tumor growth regulatory pathways and pro-apoptotic programs. Since gene expression is regulated by acetylation status of histones, a large variety of histone deacetylase (HDAC) inhibitors have been studied as antitumor agents. On the basis of their pro-apoptotic activity, HDAC inhibitors have been combined with conventional antitumor agents or novel target-specific agents to increase susceptibility to apoptosis and drug sensitivity of cancer cells. Several combination strategies including HDAC inhibitors have been explored in preclinical studies. Promising therapeutic effects have been reported in combination with DNA damaging agents, taxanes, targeted agents, death receptor agonists and hormonal therapies. Some histone deacetylases, such as HDAC6, can also modulate the function of non-histone proteins involved in critical regulatory processes which may be relevant as therapeutic targets. Given the pleiotropic effects of most of the available inhibitors, the mechanisms of the sensitization are not completely elucidated. A better understanding of the involved mechanisms will provide a rational basis to improve the therapeutic outcome of the available antitumor agents. |
| | |
Authors:
|
Paola Perego; Valentina Zuco; Laura Gatti; Franco Zunino |
Related Documents
:
|
3276757 - Allergen-induced airway hyperresponsiveness. 18179617 - Apoptosis, airway inflammation and anti-asthma therapy: from immunobiology to clinical ... 8597067 - A new mechanism for the toxicity of ozone. 9570557 - Induction of pulmonary allergic responses by antigen-specific th2 cells. 17157207 - Multi-directional cross-regulation of nk cell function during innate immune responses. 10611067 - Expression and activity of the fas antigen in bovine ovarian follicle cells. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-22 |
Journal Detail:
|
Title: Biochemical pharmacology Volume: - ISSN: 1873-2968 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
|
Fondazione IRCCS Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction ...
Next Document: Hsp90 inhibitors and drug resistance in cancer: The potential benefits of combination therapies of H...