Document Detail

Sensitization to food allergens in Iranian children with mild to moderate persistent asthma.
MedLine Citation:
PMID:  23151858     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Asthma is the most common chronic respiratory disease in childhood. The clinical presentation of asthma may worsen after food allergen ingestion in sensitized patients. To avoid nonspecific dietary restrictions in children with asthma, laboratory-based advice about foods is potentially helpful. The purpose of this study was to determine food sensitization in children with asthma.
METHODS: Seventy-nine children with mild to moderate persistent asthma were included in this study. Commercial food allergens including cow's milk, egg white, almond, potato, and soybean were used in skin prick tests. Specific IgE to 20 common food allergens was also measured in serum.
RESULTS: Twelve (15.2%) of the patients had a positive skin prick test to at least one of the five food extracts. Sensitization was detected by skin prick tests to cow's milk and egg white (each 6.3%), almond (3.8%), potato (2.5%) and soybean (1.3%). Specific IgE levels ≥0.35 kAU/L were detected in the serum of 47% of the children with asthma. The most common food allergens were cow's milk (26.6%), hazelnuts (25.3%), wheat flour (15.2%) and egg white (12.6%). Patients with a history of at least one hospital admission due to asthma attack had a higher rate of sensitization to egg.
CONCLUSIONS: In our study, food sensitization was frequent in Iranian children with asthma. Although clinical food allergy could not be evaluated because food challenge tests were not used in our study, skin prick tests and serum-specific IgE to common food allergens might be helpful in identifying children with food sensitization.
Shirin Farjadian; Mozhgan Moghtaderi; Sara Kashef; Soheila Alyasin
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Publication Detail:
Type:  Journal Article     Date:  2012-11-15
Journal Detail:
Title:  World journal of pediatrics : WJP     Volume:  8     ISSN:  1867-0687     ISO Abbreviation:  World J Pediatr     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278599     Medline TA:  World J Pediatr     Country:  China    
Other Details:
Languages:  eng     Pagination:  317-20     Citation Subset:  IM    
Allergy Research Center, University of Medical Sciences, Shiraz, Iran.
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