Document Detail


Sensitization to common food allergens is a risk factor for asthma in young Chinese children in Hong Kong.
MedLine Citation:
PMID:  12375712     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sensitization to aeroallergens is a major risk factor for asthma. Although patients frequently consider food ingestion as an asthma trigger, the relationship between serum food-specific IgE antibodies and childhood asthma in China remains unclear. We therefore conducted a case-control study on asthmatic children attending a university hospital-based outpatient clinic to investigate their pattern of food sensitization. Asthmatic patients underwent spirometric assessment, and peripheral blood was collected for serum-specific IgE antibodies to common food and inhalant allergens. Two hundred and thirty-one asthmatics (aged 9.3+/-4.3 years) and 79 age- and sex-matched controls were enrolled. The serum logarithmic total IgE concentrations in patients and controls were 2.49 and 1.92, respectively (p < 0.0001). Subjects with increased serum total IgE level were significantly more likely to have food sensitization than those with normal values (33% vs. 16%; p = 0.001). Twenty-nine (52%) of 56 asthmatics younger than 6 years old and seven (27%) of 26 age-matched controls hadfood-specific IgE in their sera (p = 0.035). Asthmatics with food-specific IgE also used more doses of as-needed bronchodilator weekly (p = 0.005). Nonetheless, no association was found between asthma diagnosis and sensitization to individual food allergens. Significant food sensitization, with food-specific IgE level above 95% predictive values for clinical food allergy as proposed by Sampson, was only found in two patients for peanut and three subjects for egg white. In conclusion, a significant association was found between asthma and the presence of food-specific IgE antibodies in young Chinese children. Significant sensitization to common foods is rare in this cohort.
Authors:
Ting-fan Leung; Christopher W K Lam; Iris H S Chan; Albert M Li; Nelson L S Tang
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  39     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-11     Completed Date:  2002-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  523-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR. leung2142@cuhk.edu.hk
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adolescent
Adrenal Cortex Hormones / therapeutic use
Allergens / administration & dosage,  adverse effects*,  immunology
Antibody Specificity / immunology
Arachis hypogaea / adverse effects,  immunology
Asian Continental Ancestry Group*
Asthma / ethnology,  immunology*,  therapy*
Case-Control Studies
Child
Child Welfare
Child, Preschool
Dose-Response Relationship, Immunologic
Egg White / adverse effects
Female
Food Hypersensitivity / ethnology,  immunology*,  therapy*
Forced Expiratory Volume / immunology
Hong Kong
Humans
Immunization*
Immunoglobulin E / blood,  immunology
Male
Milk Proteins / administration & dosage,  adverse effects,  immunology
Predictive Value of Tests
Risk Factors
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Allergens; 0/Milk Proteins; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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