| Sensitization to cockroach allergen: immune regulation and genetic determinants. | |
| | |
MedLine Citation:
|
PMID: 22272212 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Asthma is a major public health concern. Cockroach allergen exposure and cockroach allergic sensitization could contribute to the higher prevalence of asthma. However, the underlying immune mechanism and the genetic etiology remain unclear. Recent advances have demonstrated that several receptors (PAR-2, TLRs, CLRs) and their pathways mediate antigen uptake from the environment and induce allergies by signaling T cells to activate an inappropriate immune response. Cockroach-derived protease can disturb airway epithelial integrity via PAR-2 and leads to an increased penetration of cockroach allergen, resulting in activation of innate immune cells (e.g., DCs) via binding to either TLRs or CLRs. The activated DCs can direct cells of the adaptive immune system to facilitate promotion of Th2 cell response and subsequently increase risk of sensitization. Mannose receptor (MR), as a CLR, has been shown to mediate Bla g2 (purified cockroach allergen) uptake by DCs and to determine allergen-induced T cell polarization. Additionally, genetic factors may play an important role in conferring the susceptibility to cockroach sensitization. Several genes have been associated with cockroach sensitization and related phenotypes (HLA-D, TSLP, IL-12A, MBL2). In this review, we have focused on studies on the cockroach allergen induced immunologic responses and genetic basis for cockroach sensitization. |
| | |
Authors:
|
Peisong Gao |
Publication Detail:
|
Type: Journal Article Date: 2012-01-09 |
Journal Detail:
|
Title: Clinical & developmental immunology Volume: 2012 ISSN: 1740-2530 ISO Abbreviation: Clin. Dev. Immunol. Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101183692 Medline TA: Clin Dev Immunol Country: Egypt |
Other Details:
|
Languages: eng Pagination: 563760 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Different Implications of Paternal and Maternal Atopy for Perinatal IgE Production and Asthma Develo...
Next Document: A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inf...