Document Detail


Sensitization to apomorphine in pigeons: a multifactorial conditioning process.
MedLine Citation:
PMID:  25192069     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Apomorphine (apo), an unspecific direct dopamine agonist, elicits an intense and lasting pecking bout in pigeons. Apo yielded orderly dose-response functions, and repeated administrations led to sensitization. Strain and individual differences in sensitivity to apo were at least partly due to genetic factors. However, a strong cage-context dependency of the sensitization, which is indicative of conditioning, occurred in both pigeon strains studied. Apo-induced pecking and sensitization also occurred in total darkness. Pigeons could be conditioned to discriminate between an apo state and a non-apo state. A small dose of apo was effective as a conditioned stimulus when paired with a high dose as an unconditioned stimulus. The conditioned response (CR) was strongly specific to the context in which the sensitization to apo took place. The resistance to extinction of the CR could be increased through an oversensitization treatment. The incremental responses arising during the sensitization treatment and the CRs shown afterward by individual pigeons correlated significantly. The sensitization to apo in pigeons is well accounted for by a conditioning schema in which an interoceptive drug state is a conditional conditioned stimulus for the full expression of the incremental response. Variants of the scheme might also account for the sensitization of rodents to psychostimulants. A neural model that embodies the characteristics of the conditioning scheme has been proposed.
Authors:
Juan D Delius; Martin J Acerbo; Ines Krug; Jennifer Lee; Rita Leydel
Related Documents :
15807029 - Glottal open quotient in singing: measurements and correlation with laryngeal mechanism...
11248979 - Effects of consonant environment on vowel formant patterns.
11707349 - Macaque thresholds for detecting increases in intensity: effects of formant structure.
19355329 - Formant-frequency trajectories as acoustic correlates to speech perception.
2358129 - Comparison of the f0f2 and f0f1f2 processing strategies for the cochlear corporation co...
20331159 - Lexical frequency and japanese vowel devoicing.
7329749 - Orientation selectivity of the human visual system as a function of retinal eccentricit...
24625649 - Undulatory locomotion of flexible foils as biomimetic models for understanding fish pro...
8711909 - Stereoacuity and colour contrast.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-4
Journal Detail:
Title:  Behavioural pharmacology     Volume:  -     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Crystal Structure of Transglutaminase 2 with GTP Complex and Amino Acid Sequence Evidence of Evoluti...
Next Document:  Efficient Nose-to-Lung (N2L) Aerosol Delivery with a Dry Powder Inhaler.