Document Detail

Sensitization to Blomia tropicalis and Lepidoglyphus destructor in Dermatophagoides spp-allergic individuals.
MedLine Citation:
PMID:  1744365     Owner:  NLM     Status:  MEDLINE    
Serum was collected from 77 atopic subjects from Cartagena, Colombia, who had a positive skin test (greater than or equal to 3 mm) to either Dermatophagoides farinae (Df) (73) or D. pteronyssinus (Dp) (70). Twenty-nine healthy volunteers with negative allergy histories and negative skin tests were used as control subjects. RAST and RAST-inhibition assays were used to study the prevalence of specific IgE to Blomia tropicalis (Bt), Lepidoglyphus destructor (Ld), and Df. RAST results were considered positive when a serum bound greater than or equal to 1% of the total counts added; 69 atopic subjects (89.6%) were positive to Df, 66 (85.5%) to Bt, and 46 subjects (59.7%) were positive to Ld. RAST results, analyzed by regression analysis, revealed the following correlation coefficients: Df versus Bt, r = 0.59; Df versus Ld, r = 0.44; and Bt versus Ld, r = 0.52. RAST-inhibition assays with a serum pool of 11 individuals highly allergic to all three mites (mean specific IgE to all mites, greater than or equal to 18.2 percent total counts bound) demonstrated considerable cross-reactivity between Bt and Ld and moderate cross-reactivity between Df and Bt and Ld. Bt, Df, and Ld possess unique, as well as common, allergens. Sensitization to Bt and Ld is very common in mite-allergic individuals in Cartagena, Colombia.
L Puerta Llerena; E Fernández-Caldas; L R Caraballo Gracia; R F Lockey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  88     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-01-16     Completed Date:  1992-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  943-50     Citation Subset:  AIM; IM    
Laboratory of Immunology, University of Cartagena, Colombia.
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MeSH Terms
Allergens / immunology*,  isolation & purification
Antibody Specificity
Cross Reactions / immunology
Hypersensitivity / immunology*
Immunoglobulin E / blood
Mites / immunology*
Radioallergosorbent Test
Species Specificity
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E

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