Document Detail


Sensitization of resistant myeloid leukemia clone cells by anti-cancer drugs to factor-stimulating differentiation.
MedLine Citation:
PMID:  313889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies were made on the effect of cancer chemotherapeutic drugs on in vitro differentiation of a clone (R4) of mouse myeloid leukemic cells (MI) that is resistant to inducers. Treatment of the cells with 50% ascitic fluid (an inducer) plus 0.25 microgram/ml of adriamycin or 0.3 microgram/ml of daunomycin induced phagocytic activity and suppressed cell growth, but had little effect on cell viability; treatment with ascitic fluid or the drugs alone had no effect. In combination with ascitic fluid, mitomycin-C, hydroxyurea, 5-fluorouracil, or bleomycin also induced phagocytic activity, but 6-mercaptopurine, amethopterin, or aminopterin did not. These drugs also induced other differentiation-associated properties, lysozyme activity, and locomotive activity. The present results indicate that some cancer chemotherapeutic drugs sensitive resistant leukemic cells to an inducer of cell differentiation.
Authors:
M Hayashi; J Okabe; M Hozumi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Gann = Gan     Volume:  70     ISSN:  0016-450X     ISO Abbreviation:  Gann     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-10-17     Completed Date:  1979-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214471     Medline TA:  Gann     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  235-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology*
Ascitic Fluid / physiology
Cell Differentiation / drug effects*
Cell Line
Clone Cells / drug effects*
Colony-Stimulating Factors*
Daunorubicin / pharmacology
Doxorubicin / pharmacology
Fluorouracil / pharmacology
Leukemia, Myeloid / enzymology,  immunology*,  pathology
Methotrexate / pharmacology
Mitomycins / pharmacology
Muramidase / metabolism
Phagocytosis
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Colony-Stimulating Factors; 0/Mitomycins; 20830-81-3/Daunorubicin; 23214-92-8/Doxorubicin; 51-21-8/Fluorouracil; 59-05-2/Methotrexate; EC 3.2.1.17/Muramidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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