| Sensitization of resistant myeloid leukemia clone cells by anti-cancer drugs to factor-stimulating differentiation. | |
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MedLine Citation:
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PMID: 313889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were made on the effect of cancer chemotherapeutic drugs on in vitro differentiation of a clone (R4) of mouse myeloid leukemic cells (MI) that is resistant to inducers. Treatment of the cells with 50% ascitic fluid (an inducer) plus 0.25 microgram/ml of adriamycin or 0.3 microgram/ml of daunomycin induced phagocytic activity and suppressed cell growth, but had little effect on cell viability; treatment with ascitic fluid or the drugs alone had no effect. In combination with ascitic fluid, mitomycin-C, hydroxyurea, 5-fluorouracil, or bleomycin also induced phagocytic activity, but 6-mercaptopurine, amethopterin, or aminopterin did not. These drugs also induced other differentiation-associated properties, lysozyme activity, and locomotive activity. The present results indicate that some cancer chemotherapeutic drugs sensitive resistant leukemic cells to an inducer of cell differentiation. |
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Authors:
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M Hayashi; J Okabe; M Hozumi |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Gann = Gan Volume: 70 ISSN: 0016-450X ISO Abbreviation: Gann Publication Date: 1979 Apr |
Date Detail:
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Created Date: 1979-10-17 Completed Date: 1979-10-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8214471 Medline TA: Gann Country: JAPAN |
Other Details:
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Languages: eng Pagination: 235-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology* Ascitic Fluid / physiology Cell Differentiation / drug effects* Cell Line Clone Cells / drug effects* Colony-Stimulating Factors* Daunorubicin / pharmacology Doxorubicin / pharmacology Fluorouracil / pharmacology Leukemia, Myeloid / enzymology, immunology*, pathology Methotrexate / pharmacology Mitomycins / pharmacology Muramidase / metabolism Phagocytosis |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Colony-Stimulating Factors; 0/Mitomycins; 20830-81-3/Daunorubicin; 23214-92-8/Doxorubicin; 51-21-8/Fluorouracil; 59-05-2/Methotrexate; EC 3.2.1.17/Muramidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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