Document Detail

Sensitization of resistant myeloid leukemia clone cells by anti-cancer drugs to factor-stimulating differentiation.
MedLine Citation:
PMID:  313889     Owner:  NLM     Status:  MEDLINE    
Studies were made on the effect of cancer chemotherapeutic drugs on in vitro differentiation of a clone (R4) of mouse myeloid leukemic cells (MI) that is resistant to inducers. Treatment of the cells with 50% ascitic fluid (an inducer) plus 0.25 microgram/ml of adriamycin or 0.3 microgram/ml of daunomycin induced phagocytic activity and suppressed cell growth, but had little effect on cell viability; treatment with ascitic fluid or the drugs alone had no effect. In combination with ascitic fluid, mitomycin-C, hydroxyurea, 5-fluorouracil, or bleomycin also induced phagocytic activity, but 6-mercaptopurine, amethopterin, or aminopterin did not. These drugs also induced other differentiation-associated properties, lysozyme activity, and locomotive activity. The present results indicate that some cancer chemotherapeutic drugs sensitive resistant leukemic cells to an inducer of cell differentiation.
M Hayashi; J Okabe; M Hozumi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Gan     Volume:  70     ISSN:  0016-450X     ISO Abbreviation:  Gan     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-10-17     Completed Date:  1979-10-17     Revised Date:  2014-10-03    
Medline Journal Info:
Nlm Unique ID:  0151745     Medline TA:  Gan     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  235-8     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / pharmacology*
Ascitic Fluid / physiology
Cell Differentiation / drug effects*
Cell Line
Clone Cells / drug effects*
Colony-Stimulating Factors*
Daunorubicin / pharmacology
Doxorubicin / pharmacology
Fluorouracil / pharmacology
Leukemia, Myeloid / enzymology,  immunology*,  pathology
Methotrexate / pharmacology
Mitomycins / pharmacology
Muramidase / metabolism
Reg. No./Substance:
0/Antineoplastic Agents; 0/Colony-Stimulating Factors; 0/Mitomycins; 80168379AG/Doxorubicin; EC; U3P01618RT/Fluorouracil; YL5FZ2Y5U1/Methotrexate; ZS7284E0ZP/Daunorubicin

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