| Sensitization of the mesoaccumbens dopamine response to nicotine. | |
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MedLine Citation:
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PMID: 9586863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article reviews the evidence that pretreatment with nicotine causes a regionally selective sensitization of its stimulatory effects on a pathway, the mesoaccumbens dopamine (DA) system, which has been implicated in the locomotor stimulant response to nicotine and its ability to reinforce self-administration. The sensitization evoked by daily injections of nicotine is associated with a regionally selective downregulation of the control of mesoaccumbens DA neurons by inhibitory autoreceptors and depends upon co-stimulation of NMDA glutamatergic receptors. It is suggested that the sensitization is related to enhanced burst firing of mesoaccumbens neurons, which results in an enhancement of DA release into the extracellular space between the cells where it acts upon putative extrasynaptic dopamine receptors. The studies with NMDA receptor antagonists revealed a dissociation between the expression of sensitized mesoaccumbens DA and locomotor responses to nicotine. It is proposed, therefore, that the sensitized mesoaccumbens DA responses to nicotine may be implicated in psychopharmacological responses to drug concerned more closely with nicotine dependence. |
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Authors:
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D J Balfour; M E Benwell; C E Birrell; R J Kelly; M Al-Aloul |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 59 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-06-26 Completed Date: 1998-06-26 Revised Date: 2010-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1021-30 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Scotland, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dopamine / metabolism* Dopamine Uptake Inhibitors / pharmacology Humans Nicotine / pharmacology* Nicotinic Agonists / pharmacology* Nomifensine / pharmacology Nucleus Accumbens / drug effects*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Uptake Inhibitors; 0/Nicotinic Agonists; 24526-64-5/Nomifensine; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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