Document Detail


Sensitization of the mesoaccumbens dopamine response to nicotine.
MedLine Citation:
PMID:  9586863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article reviews the evidence that pretreatment with nicotine causes a regionally selective sensitization of its stimulatory effects on a pathway, the mesoaccumbens dopamine (DA) system, which has been implicated in the locomotor stimulant response to nicotine and its ability to reinforce self-administration. The sensitization evoked by daily injections of nicotine is associated with a regionally selective downregulation of the control of mesoaccumbens DA neurons by inhibitory autoreceptors and depends upon co-stimulation of NMDA glutamatergic receptors. It is suggested that the sensitization is related to enhanced burst firing of mesoaccumbens neurons, which results in an enhancement of DA release into the extracellular space between the cells where it acts upon putative extrasynaptic dopamine receptors. The studies with NMDA receptor antagonists revealed a dissociation between the expression of sensitized mesoaccumbens DA and locomotor responses to nicotine. It is proposed, therefore, that the sensitized mesoaccumbens DA responses to nicotine may be implicated in psychopharmacological responses to drug concerned more closely with nicotine dependence.
Authors:
D J Balfour; M E Benwell; C E Birrell; R J Kelly; M Al-Aloul
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  59     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-26     Completed Date:  1998-06-26     Revised Date:  2010-08-25    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1021-30     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Scotland, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dopamine / metabolism*
Dopamine Uptake Inhibitors / pharmacology
Humans
Nicotine / pharmacology*
Nicotinic Agonists / pharmacology*
Nomifensine / pharmacology
Nucleus Accumbens / drug effects*,  metabolism*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 0/Nicotinic Agonists; 24526-64-5/Nomifensine; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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