Document Detail


Sensitization due to gum arabic (Acacia senegal): the cause of occupational allergic asthma or crossreaction to carbohydrates?
MedLine Citation:
PMID:  16804326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A pharmaceutical industry worker was exposed to dust of gum arabic in the tablet coating plant and complained of work-related shortness of breath, chest tightness, runny nose, itching and redness of the eyes. This case was investigated for allergy to gum arabic and compared with a control group. The aim of the study was to identify the IgE-binding components responsible for the work-related symptoms. METHODS: Skin prick tests (SPTs)and specific IgE (sIgE) measurements with environmental and occupational allergens, spirometry and a specific bronchial challenge with gum arabic were performed. One hundred and nineteen control subjects underwent SPT with gum arabic and 43 controls were tested for sIgE. Crossreactivity between gum arabic and horse radish peroxidase was investigated by IgE CAP inhibition. A combined procedure of immunoblotting and periodate treatment was applied to identify the epitope nature of gum arabic. RESULTS: Allergy to gum arabic was shown by SPT, presence of sIgE and a positive bronchial challenge with gum arabic. Sensitization to gum arabic was demonstrated by SPT or sIgE in 7 and 5 controls, respectively. The results of inhibition with horse radish peroxidase, immunoblotting and periodate treatment suggest that gum arabic sIgE of the patient and 1 SPT-positive control subject were directed to the polypeptide chains of gum arabic. In contrast, gum arabic sIgE of the other controls reacted to carbohydrate components. CONCLUSIONS: Sensitization to gum arabic carbohydrate structures occurs casually in atopic patients with pollen sensitization without obvious exposure to gum arabic. This study suggests that allergy to gum arabic is mediated preferentially by IgE antibodies directed to polypeptide chains of gum arabic.
Authors:
Ingrid Sander; Monika Raulf-Heimsoth; Kai Wiemer; Sabine Kespohl; Thomas Brüning; Rolf Merget
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-06-27
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  141     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-16     Completed Date:  2006-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 S. Karger AG, Basel.
Affiliation:
Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Ruhr-Universität Bochum, Bochum, Deutschland. sander@bgfa.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / blood,  chemically induced*,  immunology
Bronchial Provocation Tests
Carbohydrates / immunology
Cross Reactions
Electrophoresis, Polyacrylamide Gel
Gum Arabic / adverse effects*,  chemistry
Horseradish Peroxidase / immunology
Humans
Hypersensitivity / blood,  etiology,  immunology
Immunoblotting
Immunoglobulin E / blood
Male
Occupational Diseases / blood,  chemically induced*,  immunology
Peptides / immunology
Skin Tests
Chemical
Reg. No./Substance:
0/Carbohydrates; 0/Peptides; 37341-29-0/Immunoglobulin E; 9000-01-5/Gum Arabic; EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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