| Sensitization due to gum arabic (Acacia senegal): the cause of occupational allergic asthma or crossreaction to carbohydrates? | |
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MedLine Citation:
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PMID: 16804326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A pharmaceutical industry worker was exposed to dust of gum arabic in the tablet coating plant and complained of work-related shortness of breath, chest tightness, runny nose, itching and redness of the eyes. This case was investigated for allergy to gum arabic and compared with a control group. The aim of the study was to identify the IgE-binding components responsible for the work-related symptoms. METHODS: Skin prick tests (SPTs)and specific IgE (sIgE) measurements with environmental and occupational allergens, spirometry and a specific bronchial challenge with gum arabic were performed. One hundred and nineteen control subjects underwent SPT with gum arabic and 43 controls were tested for sIgE. Crossreactivity between gum arabic and horse radish peroxidase was investigated by IgE CAP inhibition. A combined procedure of immunoblotting and periodate treatment was applied to identify the epitope nature of gum arabic. RESULTS: Allergy to gum arabic was shown by SPT, presence of sIgE and a positive bronchial challenge with gum arabic. Sensitization to gum arabic was demonstrated by SPT or sIgE in 7 and 5 controls, respectively. The results of inhibition with horse radish peroxidase, immunoblotting and periodate treatment suggest that gum arabic sIgE of the patient and 1 SPT-positive control subject were directed to the polypeptide chains of gum arabic. In contrast, gum arabic sIgE of the other controls reacted to carbohydrate components. CONCLUSIONS: Sensitization to gum arabic carbohydrate structures occurs casually in atopic patients with pollen sensitization without obvious exposure to gum arabic. This study suggests that allergy to gum arabic is mediated preferentially by IgE antibodies directed to polypeptide chains of gum arabic. |
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Authors:
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Ingrid Sander; Monika Raulf-Heimsoth; Kai Wiemer; Sabine Kespohl; Thomas Brüning; Rolf Merget |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-06-27 |
Journal Detail:
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Title: International archives of allergy and immunology Volume: 141 ISSN: 1018-2438 ISO Abbreviation: Int. Arch. Allergy Immunol. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-08-16 Completed Date: 2006-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211652 Medline TA: Int Arch Allergy Immunol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 51-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2006 S. Karger AG, Basel. |
Affiliation:
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Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Ruhr-Universität Bochum, Bochum, Deutschland. sander@bgfa.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / blood, chemically induced*, immunology Bronchial Provocation Tests Carbohydrates / immunology Cross Reactions Electrophoresis, Polyacrylamide Gel Gum Arabic / adverse effects*, chemistry Horseradish Peroxidase / immunology Humans Hypersensitivity / blood, etiology, immunology Immunoblotting Immunoglobulin E / blood Male Occupational Diseases / blood, chemically induced*, immunology Peptides / immunology Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/Carbohydrates; 0/Peptides; 37341-29-0/Immunoglobulin E; 9000-01-5/Gum Arabic; EC 1.11.1.-/Horseradish Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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