Document Detail


Sensitivity of urinary mesothelin in patients with malignant mesothelioma.
MedLine Citation:
PMID:  20815094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Malignant mesothelioma (MM) is an aggressive, uniformly fatal tumor usually caused by exposure to asbestos. Soluble mesothelin has been intensively investigated in the serum as a biomarker for this disease. As urine is less complex and less invasive to collect than serum and may be a more acceptable specimen for large-scale screening studies of asbestos-exposed individuals, we determined whether the sensitivity and specificity for MM could be improved by measuring soluble mesothelin in the urine.
METHODS: Soluble mesothelin concentrations were determined using the MESOMARK assay in concurrent serum and urine samples from 70 patients with pleural MM, 111 patients with asbestos-related lung or pleural disease, and 45 patients with benign nonasbestos-related lung and pleural disease. Only patients with serum creatinine levels within the normal range were included in the study. Sensitivities were determined and receiver operator characteristic curves were generated to compare the diagnostic accuracy of mesothelin in the serum and urine.
RESULTS: At a specificity of 95% relative to individuals with benign lung or pleural disease, serum mesothelin had a sensitivity of 66% and area under the curve of 0.882, whereas urinary mesothelin corrected for urine creatinine concentration had a sensitivity of 53% and area under the curve of 0.787.
CONCLUSIONS: The sensitivity of urinary mesothelin does not warrant the use of urine as a biomarker specimen for MM diagnosis.
Authors:
Jenette Creaney; Arthur W Musk; Bruce W S Robinson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer     Volume:  5     ISSN:  1556-1380     ISO Abbreviation:  J Thorac Oncol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-12-14     Revised Date:  2011-10-26    
Medline Journal Info:
Nlm Unique ID:  101274235     Medline TA:  J Thorac Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1461-6     Citation Subset:  IM    
Affiliation:
National Centre for Asbestos Related Diseases, Western Australian Institute of Medical Research, School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia. creaneyj@cyllene.uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Asbestos / adverse effects*
Asbestosis / blood,  urine
Case-Control Studies
Creatinine / urine
Female
GPI-Linked Proteins / blood,  urine
Glomerular Filtration Rate
Humans
Idiopathic Pulmonary Fibrosis / blood,  chemically induced,  urine
Immunoblotting
Male
Membrane Glycoproteins / blood,  urine*
Mesothelioma / blood,  drug therapy,  urine*
Middle Aged
Pleural Neoplasms / blood,  drug therapy,  urine*
Prognosis
ROC Curve
Sarcoidosis, Pulmonary / blood,  chemically induced,  urine
Sensitivity and Specificity
Survival Rate
Tumor Markers, Biological / metabolism,  urine*
Young Adult
Chemical
Reg. No./Substance:
0/GPI-Linked Proteins; 0/Membrane Glycoproteins; 0/Tumor Markers, Biological; 0/mesothelin; 1332-21-4/Asbestos; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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