| Sensitivity to endotoxin in rabbits is increased after hemorrhagic shock. | |
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MedLine Citation:
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PMID: 1400029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immunoinflammatory response following trauma and hemorrhage may predispose to the development of sepsis and multiple-organ failure syndrome. Cardiac output (CO), arterial pressure, arterial PO2, and pulmonary permeability index were measured. We examined the sensitivity of rabbits to infusions of lipopolysaccharide (LPS) after hemorrhagic shock. Shock was produced by reducing CO to 40% of baseline for 90 min, followed by resuscitation with shed blood and then with lactated Ringer solution to maintain CO near baseline. Animals were assigned to three groups: 1) hemorrhagic shock only, 2) LPS only, and 3) hemorrhagic shock + LPS. Groups 1 and 3 were subjected to hemorrhagic shock on day 1. Escherichia coli LPS was infused (1.0 microgram/kg i.v.) into groups 2 and 3 on day 2. Fluid resuscitation with lactated Ringer solution was continued in an effort to maintain CO at baseline. Five hours after LPS infusion, 125I-albumin was injected intravenously, and rabbits were killed 1 h later for measurement of pulmonary permeability index. LPS infusion after shock (group 3) caused significant decreases in CO, arterial pressure, and PO2 and an increase in pulmonary permeability. These changes were not seen in the groups 1 and 2. We conclude that hemorrhagic shock and resuscitation result in a proinflammatory state, leading to increased sensitivity to subsequent exposure to LPS. |
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Authors:
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W J Mileski; R K Winn; J M Harlan; C L Rice |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 73 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-11-23 Completed Date: 1992-11-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1146-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Washington School of Medicine, Seattle 98104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endotoxins / toxicity* Inflammation / complications, physiopathology Lipopolysaccharides / toxicity Lung / physiopathology Multiple Organ Failure / etiology Permeability Rabbits Shock, Hemorrhagic / complications, physiopathology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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GM-07037/GM/NIGMS NIH HHS; HL-30542/HL/NHLBI NIH HHS; HL-43141/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Lipopolysaccharides |
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