Document Detail


Sensitivity to activated protein C during the menstrual cycle in women with and without factor VLeiden.
MedLine Citation:
PMID:  17936879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Activated protein C (APC) resistance is associated with an increased risk of venous thrombosis. High levels of estradiol and progesterone, e.g. during ovarian stimulation and pregnancy, as well as exogenously administered estrogens and progestagens during oral contraceptive use, induce an acquired form of APC resistance. Several coagulation factors display a cyclic pattern during the menstrual cycle due to the fluctuation of estradiol and progesterone. The aim of the study was to evaluate whether varying levels of estradiol and progesterone during the menstrual cycle are associated with differences in sensitivity to APC. MATERIALS AND METHODS: Normalized APC sensitivity ratios (nAPCsr) were determined with the thrombin generation-based APC-resistance test at six different time points during the menstrual cycle in thirteen wildtype women and six women with factor VLeiden. RESULTS: Mean nAPCsr varied slightly during the menstrual cycle. Women without factor VLeiden were more likely to have lower nAPCsr at the beginning of the cycle than later on in the cycle (1.34 versus 1.54 and 1.58, Friedman ranking test p=0.009). CONCLUSIONS: The sensitivity to APC differs between the different phases of the menstrual cycle. This cyclic variability could be useful in improving studies on APC resistance in women.
Authors:
Huib A A M van Vliet; Sharon P Rodrigues; Marieke N E Snieders; Felix J M van der Meer; Marijke Frolich; Frits R Rosendaal; Jan Rosing; Frans M Helmerhorst
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Publication Detail:
Type:  Journal Article     Date:  2007-10-22
Journal Detail:
Title:  Thrombosis research     Volume:  121     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  757-61     Citation Subset:  IM    
Affiliation:
Department of Gynaecology, Division of Reproductive Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. haam.vliet@worldonline.nl
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MeSH Terms
Descriptor/Qualifier:
Activated Protein C Resistance / blood
Adult
Blood Coagulation Tests
Estradiol / blood*
Factor V / analysis*,  genetics
Female
Humans
Menstrual Cycle / blood*
Mutation
Polymerase Chain Reaction / methods
Progesterone / blood*
Protein C* / pharmacology
Prothrombin / genetics
Reference Values
Sensitivity and Specificity
Thrombin / chemistry,  drug effects
Time Factors
Chemical
Reg. No./Substance:
0/Protein C; 0/factor V Leiden; 50-28-2/Estradiol; 57-83-0/Progesterone; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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