| Sensitivity and specificity of confocal scan in the diagnosis of infectious keratitis. | |
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MedLine Citation:
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PMID: 17667609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the sensitivity and specificity of confocal scan with the results of corneal and/or contact lens case smear and culture in the diagnosis of infectious keratitis. METHODS: This was a diagnostic test study. Confocal scan and corneal and/or contact lens case smear and culture were performed in all patients with a clinical diagnosis of infectious keratitis at Labbafinejad Medical Center from 2004 to 2006. RESULTS: A total of 133 eyes of 133 patients with a mean age of 48.0 +/- 22.6 years (range, 9-83 years) were included in the study. Sixty-nine (51.9%) cases were men, and 64 (48.1%) were women. Twenty-eight cases (21%) were contact lens wearers; history of trauma and previous ocular surgery was present in 21% and 38.3%, respectively. Corneal and/or contact lens case smear and culture were positive in 71 eyes (53.4%), including 40 cases of bacterial, 16 cases of fungal, and 15 cases of acanthamoeba infection. Confocal scan was positive in 50 cases (37.6%), which revealed hyphae-like structures in 27 cases and cyst and/or trophozoite-like structures in 23 cases. The sensitivity and specificity of confocal scans were 100% and 84% for the diagnosis of acanthamoeba keratitis versus 94% and 78% for fungal keratitis, respectively. CONCLUSIONS: In vivo corneal confocal scan is a rapid noninvasive tool for the diagnosis of acanthamoeba and fungal keratitis with high sensitivity and specificity compared with smear and culture. It may also be helpful in excluding fungal or acanthamoeba-like structures in cases with negative bacteriologic results and in early bacterial keratitis before clarification of microbiologic results. |
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Authors:
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Mozhgan Rezaei Kanavi; Mohammadali Javadi; Shahin Yazdani; Seyedali Mirdehghanm |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cornea Volume: 26 ISSN: 0277-3740 ISO Abbreviation: Cornea Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-01 Completed Date: 2007-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 782-6 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Shahid Beheshti Medical University, Tehran, Iran. manager@iraneyebank.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acanthamoeba
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isolation & purification Adolescent Adult Aged Aged, 80 and over Animals Bacteria / isolation & purification Bacteriological Techniques Child Contact Lenses / microbiology Corneal Ulcer / diagnosis*, microbiology Diagnostic Techniques, Ophthalmological / standards* Eye Infections / diagnosis*, microbiology Female Fungi / isolation & purification Humans Male Microscopy, Confocal / standards* Middle Aged Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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