Document Detail

Sensitivity of the renal medullary circulation to plasma vasopressin.
MedLine Citation:
PMID:  8853387     Owner:  NLM     Status:  MEDLINE    
Studies were carried out to determine the effects of physiological changes of plasma arginine vasopressin (AVP) on blood flow distribution in the renal cortex and medulla. Acute decerebration was performed so that studies could be carried out within the low physiological range of circulating AVP. Changes of renal cortical and medullary microcirculatory blood flow were measured with implanted optical fibers and laser-Doppler flowmetry, and total renal blood flow was measured with transit-time ultrasonography. During intravenous infusion of increasing doses of AVP, when plasma AVP was increased in steps from 2.9 to 11.2 pg/ml by intravenous infusion, mean arterial pressure (98 +/- 3 mmHg), total renal blood flow (8.2 +/- 0.6 ml. min-1.g kidney-1), and blood flow in the microcirculation of the cortex (2.11 +/- 0.28 V) remained unchanged, whereas that in the renal medulla decreased progressively. Medullary flow was significantly reduced when circulating levels of AVP increased from a control level of 2.8 to 5.0 pg/ml. The reductions of medullary flow were accompanied by parallel increases of urine osmolality. These data indicate that the vessels supplying the renal medullary circulation are sensitive within the range of plasma AVP concentrations observed with moderate water restriction. The medullary circulation exhibits a sensitivity AVP that parallels that found in the medullary collecting ducts.
K G Franchini; A W Cowley
Related Documents :
7998827 - Inhalation toxicokinetics of butoxyethanol and its metabolite butoxyacetic acid in the ...
10813367 - Et-receptor subtypes: roles in regional renal vascular actions of exogenous and endogen...
8172747 - In vivo fluorescence microscopy of microcirculation in the renal cortex of mice. part v...
1175177 - The effect of noradrenaline, adrenergic blocking agents, and tyramine on the intrarenal...
3401767 - Dynamic cerebral and systemic circulatory effects of adenosine, theophylline and dipyri...
1242857 - Laboratory diagnosis of the atopic condition: evaluation of a possible method based on ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R647-53     Citation Subset:  IM    
Heart Institute, University of São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arginine Vasopressin / blood*
Blood Proteins / analysis
Electrolytes / urine
Kidney Medulla / blood supply
Osmolar Concentration
Rats, Sprague-Dawley
Renal Circulation*
Sodium / blood
Urine / chemistry
Grant Support
Reg. No./Substance:
0/Blood Proteins; 0/Electrolytes; 113-79-1/Arginine Vasopressin; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of cardiac output in mediating arterial blood pressure oscillations.
Next Document:  Conscious obese rats have impaired reflex bradycardia and enhanced norepinephrine sensitivity.