Document Detail


Sensitivity of the renal medullary circulation to plasma vasopressin.
MedLine Citation:
PMID:  8853387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies were carried out to determine the effects of physiological changes of plasma arginine vasopressin (AVP) on blood flow distribution in the renal cortex and medulla. Acute decerebration was performed so that studies could be carried out within the low physiological range of circulating AVP. Changes of renal cortical and medullary microcirculatory blood flow were measured with implanted optical fibers and laser-Doppler flowmetry, and total renal blood flow was measured with transit-time ultrasonography. During intravenous infusion of increasing doses of AVP, when plasma AVP was increased in steps from 2.9 to 11.2 pg/ml by intravenous infusion, mean arterial pressure (98 +/- 3 mmHg), total renal blood flow (8.2 +/- 0.6 ml. min-1.g kidney-1), and blood flow in the microcirculation of the cortex (2.11 +/- 0.28 V) remained unchanged, whereas that in the renal medulla decreased progressively. Medullary flow was significantly reduced when circulating levels of AVP increased from a control level of 2.8 to 5.0 pg/ml. The reductions of medullary flow were accompanied by parallel increases of urine osmolality. These data indicate that the vessels supplying the renal medullary circulation are sensitive within the range of plasma AVP concentrations observed with moderate water restriction. The medullary circulation exhibits a sensitivity AVP that parallels that found in the medullary collecting ducts.
Authors:
K G Franchini; A W Cowley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R647-53     Citation Subset:  IM    
Affiliation:
Heart Institute, University of São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine Vasopressin / blood*
Blood Proteins / analysis
Diuresis
Electrolytes / urine
Hematocrit
Hemodynamics
Kidney Medulla / blood supply
Male
Osmolar Concentration
Rats
Rats, Sprague-Dawley
Renal Circulation*
Sodium / blood
Urine / chemistry
Grant Support
ID/Acronym/Agency:
R01 HL-49219/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Electrolytes; 113-79-1/Arginine Vasopressin; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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