Document Detail

Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity.
MedLine Citation:
PMID:  20920818     Owner:  NLM     Status:  MEDLINE    
The prevalence of allergic-related diseases, food intolerance, and chemical sensitivities in both the pediatric and adult population has increased dramatically over the last two decades, with escalating rates of associated morbidity. Conditions of acquired allergy, food intolerance and chemical hypersensitivity are frequently the direct sequelae of a toxicant induced loss of tolerance (TILT) in response to a significant initiating toxic exposure. Following the primary toxicant insult, the individuals become sensitive to low levels of diverse and unrelated triggers in their environment such as commonly encountered chemical, inhalant or food antigens. Among sensitized individuals, exposure to assorted inciting stimuli may precipitate diverse clinical and/or immune sequelae as may be evidenced by clinical symptoms as well as varied lymphocyte, antibody, or cytokine responses in some cases. Recently recognized as a mechanism of disease development, TILT and resultant sensitivity-related illness (SRI) may involve various organ systems and evoke wide-ranging physical or neuropsychological manifestations. With escalating rates of toxicant exposure and bioaccumulation in the population-at-large, an increasing proportion of contemporary illness is the direct result of TILT and ensuing SRI. Avoidance of triggers will preclude symptoms, and desensitization immunotherapy or immune suppression may ameliorate symptomatology in some cases. Resolution of SRI generally occurs on a gradual basis following the elimination of bioaccumulated toxicity and avoidance of further initiating adverse environmental exposures. As has usually been the case throughout medical history whenever new evidence regarding disease mechanisms emerges, resistance to the translation of knowledge abounds.
Stephen J Genuis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Science of the total environment     Volume:  408     ISSN:  1879-1026     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  6047-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Environmental Health Sciences, Faculty Of Medicine, University Of alberta, Canada.
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MeSH Terms
Autoimmunity / drug effects
Biological Markers / metabolism
Chronic Disease / epidemiology
Environmental Exposure
Environmental Pollutants / toxicity
Food Hypersensitivity / epidemiology,  etiology,  metabolism
Hypersensitivity / epidemiology*,  etiology,  metabolism
Multiple Chemical Sensitivity / epidemiology*,  etiology,  metabolism
Reg. No./Substance:
0/Biological Markers; 0/Environmental Pollutants

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