Document Detail

Sensitivity and permeability of the anthramycin producing organism Streptomyces refuineus to anthramycin and structurally related antibiotics.
MedLine Citation:
PMID:  6895748     Owner:  NLM     Status:  MEDLINE    
Streptomyces refuineus, the microorganism which produces the DNA reactive antibiotic anthramycin, has shown to possess a quite specific mechanism to survive and grow in the presence of this antibiotic. Stationary phase cells are insensitive to anthramycin since the antibiotic is prevented form entering these cells. However, cells in early log phase are inhibited by concentrations of anthramycin that are later produced by these same cells. Significantly, sibiromycin, a closely related antibiotic, is taken up by cells of S. refuineus independent of the age of the culture. Anthramycin reacts in vitro equally as well as DNA isolated from S. refuineus and other procaryotic and eucaryotic cells. When S. refuineus has reached the production phase the anthramycin is probably biosynthesized outside the cell membrane which also becomes specifically impermeable to anthramycin.
J S Rokem; L H Hurley
Related Documents :
3653258 - Relationship between cytoplasmic ph and proliferation during exponential growth and cel...
7796698 - Induction of cell cycle perturbations by the tear gas 2-chlorobenzylidene malonitrile i...
22694258 - Combined atomic force microscopy - fluorescence microscopy: analyzing exocytosis at alv...
2446768 - Fractionation of k-562 cells on the basis of their surface properties by partitioning i...
23105118 - The m2 module of the cys-his-rich domain (chrd) of pcsk9 protein is needed for the extr...
7217008 - Metabolism of resorcinylic compounds by bacteria: new pathway for resorcinol catabolism...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  34     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1171-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anthramycin / biosynthesis,  metabolism,  pharmacology*
Anti-Bacterial Agents / metabolism,  pharmacology*
Antibiotics, Antineoplastic / pharmacology*
Benzodiazepinones / pharmacology*
Cell Membrane Permeability
Streptomyces / drug effects*,  metabolism
Grant Support
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Antibiotics, Antineoplastic; 0/Benzodiazepinones; 12684-33-2/sibiromycin; 35050-55-6/tomaymycin; 4803-27-4/Anthramycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lymphosarcoma in an Eastern king snake and a rhinoceros viper.
Next Document:  Synthesis of acetyl coenzyme A from carbon monoxide, methyltetrahydrofolate, and coenzyme A by enzym...