Document Detail


Sensitivity and permeability of the anthramycin producing organism Streptomyces refuineus to anthramycin and structurally related antibiotics.
MedLine Citation:
PMID:  6895748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Streptomyces refuineus, the microorganism which produces the DNA reactive antibiotic anthramycin, has shown to possess a quite specific mechanism to survive and grow in the presence of this antibiotic. Stationary phase cells are insensitive to anthramycin since the antibiotic is prevented form entering these cells. However, cells in early log phase are inhibited by concentrations of anthramycin that are later produced by these same cells. Significantly, sibiromycin, a closely related antibiotic, is taken up by cells of S. refuineus independent of the age of the culture. Anthramycin reacts in vitro equally as well as DNA isolated from S. refuineus and other procaryotic and eucaryotic cells. When S. refuineus has reached the production phase the anthramycin is probably biosynthesized outside the cell membrane which also becomes specifically impermeable to anthramycin.
Authors:
J S Rokem; L H Hurley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  34     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1171-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminoglycosides*
Anthramycin / biosynthesis,  metabolism,  pharmacology*
Anti-Bacterial Agents / metabolism,  pharmacology*
Antibiotics, Antineoplastic / pharmacology*
Benzodiazepinones / pharmacology*
Cell Membrane Permeability
Streptomyces / drug effects*,  metabolism
Grant Support
ID/Acronym/Agency:
CA 17047/CA/NCI NIH HHS; RR 09166/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Antibiotics, Antineoplastic; 0/Benzodiazepinones; 12684-33-2/sibiromycin; 35050-55-6/tomaymycin; 4803-27-4/Anthramycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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