Document Detail

Sensitivity of offspring to chronic 3,4-dichloroaniline exposure varies with maternal exposure.
MedLine Citation:
PMID:  15223266     Owner:  NLM     Status:  MEDLINE    
Many anthropogenic pollutants are present in aquatic systems for extended periods of time. Populations in the field may be exposed to toxicants for several generations, which may affect their sensitivity to toxicants. Ceriodaphnia cf. dubia mass cultures were maintained for four generations in various concentrations of 3,4-dichoroaniline (0, 2.5, 5, 10, and 15 microg/L) and were reestablished every generation using fourth-brood neonates. Each generation, chronic toxicity tests were initiated using fourth-brood neonates from each mass culture treatment. Significantly (P < 0.05) reduced sensitivity to 3,4-dichloroaniline compared to control animals was shown by F1 offspring from mothers exposed to 15 microg/L, F2 offspring from mothers exposed to 5, 10, and 15 microg/L, F3 offspring from mothers exposed to 10 and 15 microg/L, and F4 offspring from mothers exposed to all 3,4-dichloroaniline treatments (2.5, 5, 10, and 15 microg/L). Possible explanations for the development of tolerance, and the possible implications of tolerance, are discussed.
Rebecca M Rose; Michael St J Warne; Richard P Lim
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  58     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-29     Completed Date:  2005-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
Department of Environmental Sciences, University of Technology, Sydney, Australia.
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MeSH Terms
Adaptation, Physiological / genetics
Aniline Compounds / toxicity*
Animals, Newborn
Cladocera / drug effects*,  genetics
Drug Tolerance / genetics
Inhibitory Concentration 50
Time Factors
Toxicity Tests, Chronic
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Aniline Compounds; 0/Water Pollutants, Chemical; 95-76-1/3,4-dichloroaniline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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