| Sensitivity of offspring to chronic 3,4-dichloroaniline exposure varies with maternal exposure. | |
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MedLine Citation:
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PMID: 15223266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many anthropogenic pollutants are present in aquatic systems for extended periods of time. Populations in the field may be exposed to toxicants for several generations, which may affect their sensitivity to toxicants. Ceriodaphnia cf. dubia mass cultures were maintained for four generations in various concentrations of 3,4-dichoroaniline (0, 2.5, 5, 10, and 15 microg/L) and were reestablished every generation using fourth-brood neonates. Each generation, chronic toxicity tests were initiated using fourth-brood neonates from each mass culture treatment. Significantly (P < 0.05) reduced sensitivity to 3,4-dichloroaniline compared to control animals was shown by F1 offspring from mothers exposed to 15 microg/L, F2 offspring from mothers exposed to 5, 10, and 15 microg/L, F3 offspring from mothers exposed to 10 and 15 microg/L, and F4 offspring from mothers exposed to all 3,4-dichloroaniline treatments (2.5, 5, 10, and 15 microg/L). Possible explanations for the development of tolerance, and the possible implications of tolerance, are discussed. |
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Authors:
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Rebecca M Rose; Michael St J Warne; Richard P Lim |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ecotoxicology and environmental safety Volume: 58 ISSN: 0147-6513 ISO Abbreviation: Ecotoxicol. Environ. Saf. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-29 Completed Date: 2005-02-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805381 Medline TA: Ecotoxicol Environ Saf Country: United States |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: IM |
Affiliation:
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Department of Environmental Sciences, University of Technology, Sydney, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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genetics Aniline Compounds / toxicity* Animals Animals, Newborn Cladocera / drug effects*, genetics Drug Tolerance / genetics Female Inhibitory Concentration 50 Time Factors Toxicity Tests, Chronic Water Pollutants, Chemical / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Aniline Compounds; 0/Water Pollutants, Chemical; 95-76-1/3,4-dichloroaniline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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