Document Detail

Sensitivity of the nictitating membrane of the cat to succinylcholine after decentralization and denervation.
MedLine Citation:
PMID:  4724189     Owner:  NLM     Status:  MEDLINE    
Seven days after decentralization or denervation, the nictitating membrane of the cat becomes supersensitive to succinylcholine. The supersensitivity to succinylcholine is of a moderate degree (2-3 fold) and there is little difference between the supersensitivity induced by decentralization or denervation. In this respect, it is similar to the decentralization type of supersensitivity observed for other agonists which are not taken up by the adrenergic nerve endings (e.g. acetylcholine and methoxamine). Since succinyloholine causes an apparent contraction of the nictitating membrane through its action on the extraocular muscle and no effect on the nictitating membrane itself, it is concluded that both chronic decentralization and denervation produced a decentralization type supersensitivity in the extraocular muscles. The results suggest that supersensitivity in the extraocular muscles may contribute significantly to the decentralization supersensitivity of the nictitating membrane of the cat, in vivo, especially for those agonists which cause contractions of both the nictitating membrane and the extraocular muscle.
T H Tsai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  48     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1973 May 
Date Detail:
Created Date:  1973-10-12     Completed Date:  1973-10-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  172-4     Citation Subset:  IM    
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MeSH Terms
Central Nervous System / physiology
Chlorisondamine / pharmacology
Dose-Response Relationship, Drug
Muscle Contraction / drug effects
Muscles / drug effects
Nictitating Membrane / drug effects*
Succinylcholine / administration & dosage,  pharmacology*
Reg. No./Substance:
306-40-1/Succinylcholine; 7701-62-4/Chlorisondamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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