Document Detail


Sensitivity of human pulmonary mast cells obtained by bronchoalveolar lavage to immunological and nonimmunological histamine releasers.
MedLine Citation:
PMID:  2461646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied the sensitivity of human pulmonary mast cells to some immunological and nonimmunological histamine releasers. The pulmonary mast cells were obtained by bronchoalveolar lavage (BAL) of nonasthmatic patients. Mast cells constituted about 1% of total cell population and were morphologically intact. These cells were highly sensitive to the challenge with anti-human IgE. They responded to calcium ionophore A23187, polymyxin B and concanavalin A, however the magnitude of histamine release was low. BAL mast cells were unresponsive to the compound 48/80.
Authors:
E Brezińska-Blaszcyk; A Gaik; K Rydzyński; A Szymański
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergie und Immunologie     Volume:  34     ISSN:  0323-4398     ISO Abbreviation:  Allerg Immunol (Leipz)     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-11     Completed Date:  1989-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0314702     Medline TA:  Allerg Immunol (Leipz)     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  169-75     Citation Subset:  IM    
Affiliation:
Department of Biogenic Amines, Polish Academy of Sciences, Lódź.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Anti-Idiotypic / immunology
Bronchoalveolar Lavage Fluid / cytology
Calcimycin / pharmacology
Concanavalin A / pharmacology
Histamine Release / drug effects
Humans
Immunoglobulin E / immunology
Mast Cells / immunology*
Polymyxin B / pharmacology
Pulmonary Alveoli / cytology*
p-Methoxy-N-methylphenethylamine / pharmacology
Chemical
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 11028-71-0/Concanavalin A; 1404-26-8/Polymyxin B; 37341-29-0/Immunoglobulin E; 4091-50-3/p-Methoxy-N-methylphenethylamine; 52665-69-7/Calcimycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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