| Sensitivity of fluorophore-quencher labeled microbubbles to externally applied static pressure. | |
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MedLine Citation:
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PMID: 19746779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A fluorophore-quencher (F-Q) labeled microbubble system is proposed as a sensor for measuring externally applied static pressure distribution in a tumor. To quantify the sensitivity of such an F-Q bubble system to the externally applied pressure, a model describing bubble response to the static pressure was derived. Additionally, a model connecting the fluorescence lifetime and bubble radius was developed for the basic F-Q bubble system. The sensitivity is quantified based on these models given typical parameters. Results show that it is possible to resolve as low as 1 mm Hg pressure variation when both the F-Q bubble system and the measurement system are optimized. Strategies for optimizing an F-Q bubble system are discussed. |
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Authors:
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Baohong Yuan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical physics Volume: 36 ISSN: 0094-2405 ISO Abbreviation: - Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-09-14 Completed Date: 2009-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425746 Medline TA: Med Phys Country: United States |
Other Details:
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Languages: eng Pagination: 3455-69 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Catholic University of America, Washington, DC 20064, USA. yuan@cua.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Feasibility Studies Fluorescence Fluorescent Dyes / metabolism* Microbubbles* Models, Biological Neoplasms / metabolism, physiopathology Pressure* Staining and Labeling Surface Tension Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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