Document Detail

Sensitivity enhancement by exchange mediated magnetization transfer of the xenon biosensor signal.
MedLine Citation:
PMID:  17046295     Owner:  NLM     Status:  MEDLINE    
Hyperpolarized xenon associated with ligand derivatized cryptophane-A cages has been developed as a NMR based biosensor. To optimize the detection sensitivity we describe use of xenon exchange between the caged and bulk dissolved xenon as an effective signal amplifier. This approach, somewhat analogous to 'remote detection' described recently, uses the chemical exchange to repeatedly transfer spectroscopic information from caged to bulk xenon, effectively integrating the caged signal. After an optimized integration period, the signal is read out by observation of the bulk magnetization. The spectrum of the caged xenon is reconstructed through use of a variable evolution period before transfer and Fourier analysis of the bulk signal as a function of the evolution time.
Sandra Garcia; Lana Chavez; Thomas J Lowery; Song-I Han; David E Wemmer; Alexander Pines
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-10-13
Journal Detail:
Title:  Journal of magnetic resonance (San Diego, Calif. : 1997)     Volume:  184     ISSN:  1090-7807     ISO Abbreviation:  J. Magn. Reson.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-12     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9707935     Medline TA:  J Magn Reson     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-7     Citation Subset:  IM    
Materials Science Division, Lawrence Berkeley National Laboratory, USA; Department of Chemistry, University of California, Berkeley, CA 94720, USA.
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MeSH Terms
Biosensing Techniques / methods*
Magnetic Resonance Spectroscopy / methods*
Microchemistry / methods*
Reproducibility of Results
Sensitivity and Specificity
Xenon / analysis*,  chemistry*
Reg. No./Substance:

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