| Sensitivity disturbances in patients with irritable bowel syndrome and fibromyalgia. | |
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MedLine Citation:
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PMID: 17227524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although visceral hypersensitivity is a common feature among patients with irritable bowel syndrome (IBS), studies on somatic sensitivity have given controversial results. AIM: To assess visceral sensitivity in response to isotonic rectal distensions and somatic sensitivity at different layers of the body wall (skin, subcutis, and muscle) in patients with IBS and fibromyalgia (FM), within and outside the area of abdominal pain referral. MATERIALS AND METHODS: We studied 10 patients with IBS, 5 patients with FM, 9 patients with IBS+FM, and 9 healthy controls. Rectal distensions were performed by increasing tension at 4 g steps up to 64 g or discomfort. Pain thresholds to electrical stimulation were measured within and outside the areas of abdominal pain referral. RESULTS: Patients with IBS and IBS+FM demonstrated rectal hypersensitivity in comparison to controls. The threshold of discomfort was 44 +/- 5 g in IBS and 36 +/- 5 in IBS+FM patients, while patients with FM and healthy controls tolerated all distensions without discomfort. In the areas of pain referral, pain thresholds of all three tissues of the body wall were lower than normal in all patients groups (p < 0.001). In control areas, the pain thresholds were normal in skin, and lower than normal in subcutis and muscle in IBS (p < 0.001). FM and IBS+FM demonstrated somatic hypersensitivity at all sites (p < 0.001 vs healthy). CONCLUSION: Our observations seem to indicate that, although sharing a common hypersensitivity background, multiple mechanisms may modulate perceptual somatic and visceral responses in patients with IBS and FM. |
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Authors:
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Maria P Caldarella; Maria A Giamberardino; Flora Sacco; Giannapia Affaitati; Angelo Milano; Rosanna Lerza; Crysanthi Balatsinou; Francesco Laterza; Sante D Pierdomenico; Franco Cuccurullo; Matteo Neri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 101 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2007-01-17 Completed Date: 2007-02-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 2782-9 Citation Subset: IM |
Affiliation:
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Department of Medicine and Aging Sciences, Section of Internal Medicine and Gastroenterology, Centre for the Study of Aging, Gabriele D'Annunzio University and Foundation, Chieti, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Female Fibromyalgia / complications, physiopathology*, psychology Humans Irritable Bowel Syndrome / complications, physiopathology*, psychology Male Muscle, Skeletal / physiopathology Pain Threshold / physiology* Physical Stimulation Rectum / physiopathology Skin / physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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