Document Detail


Sensitivity of different phases of the cell cycle to selected hepatotoxins in cultured liver-derived (BL9L) cells.
MedLine Citation:
PMID:  3138828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Many toxins are active against dividing cells and cytofluorometric analysis of synchronized dividing liver-derived (BL9L) cells has been employed to study the relative sensitivity of the G1(G0), S and G2/M phases of the cell cycle to selected hepatotoxins. 2. The cytotoxic metal beryllium, which inhibits cell division, caused a specific block at the G1 phase of the cell cycle. 3. Dehydroretronecine, an antimitotic metabolite of the hepatotoxic plant pyrrolizidine alkaloids, retarded progression of cells through the cell cycle with a consistent accumulation at the late S to G2 phase. 4. Exposure of cells to aflatoxin B1-8,9-epoxide, the putative carcinogenic metabolite of the hepatocarcinogen aflatoxin B1, particularly during the early period of S phase, produced morphologically transformed cells.
Authors:
D N Skilleter; A R Mattocks; G E Neal
Related Documents :
16023288 - Anti-proliferative effect of apigenin and its apoptotic induction in human hep g2 cells.
11525608 - Baicalein, a novel apoptotic agent for hepatoma cell lines: a potential medicine for he...
9497028 - Heterogeneity of dna content and expression of cell cycle genes in axenically growing e...
9133608 - Synthesis of lipid-linked oligosaccharides is dependent on the cell cycle in rat 3y1 ce...
21996088 - Strong anti-tumor effect of nvp-auy922, a novel hsp90 inhibitor, on non-small cell lung...
19377088 - Analysis of cerebrospinal fluid from 20 calves after storage for 24 hours.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  18     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-10-20     Completed Date:  1988-10-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  699-705     Citation Subset:  IM    
Affiliation:
MRC Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aflatoxin B1
Aflatoxins / toxicity
Animals
Carcinogens / toxicity
Cell Cycle / drug effects*
Cell Line
Drug Evaluation, Preclinical / methods
Epithelial Cells
Epithelium / drug effects
Flow Cytometry / methods
Liver / cytology,  drug effects,  pathology*
Monocrotaline* / analogs & derivatives*
Pyrrolizidine Alkaloids / toxicity
Toxins, Biological / pharmacology
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Carcinogens; 0/Pyrrolizidine Alkaloids; 0/Toxins, Biological; 1162-65-8/Aflatoxin B1; 26400-45-3/dehydroretronecine; 315-22-0/Monocrotaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The inducing and inhibiting effects of sodium valproate in vivo on the biotransformation systems of ...
Next Document:  Development of inactivated vaccine against virus causing haemorrhagic fever with renal syndrome.