Document Detail

Sensitivity of different phases of the cell cycle to selected hepatotoxins in cultured liver-derived (BL9L) cells.
MedLine Citation:
PMID:  3138828     Owner:  NLM     Status:  MEDLINE    
1. Many toxins are active against dividing cells and cytofluorometric analysis of synchronized dividing liver-derived (BL9L) cells has been employed to study the relative sensitivity of the G1(G0), S and G2/M phases of the cell cycle to selected hepatotoxins. 2. The cytotoxic metal beryllium, which inhibits cell division, caused a specific block at the G1 phase of the cell cycle. 3. Dehydroretronecine, an antimitotic metabolite of the hepatotoxic plant pyrrolizidine alkaloids, retarded progression of cells through the cell cycle with a consistent accumulation at the late S to G2 phase. 4. Exposure of cells to aflatoxin B1-8,9-epoxide, the putative carcinogenic metabolite of the hepatocarcinogen aflatoxin B1, particularly during the early period of S phase, produced morphologically transformed cells.
D N Skilleter; A R Mattocks; G E Neal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  18     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-10-20     Completed Date:  1988-10-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  699-705     Citation Subset:  IM    
MRC Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey, UK.
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MeSH Terms
Aflatoxin B1
Aflatoxins / toxicity
Carcinogens / toxicity
Cell Cycle / drug effects*
Cell Line
Drug Evaluation, Preclinical / methods
Epithelial Cells
Epithelium / drug effects
Flow Cytometry / methods
Liver / cytology,  drug effects,  pathology*
Monocrotaline* / analogs & derivatives*
Pyrrolizidine Alkaloids / toxicity
Toxins, Biological / pharmacology
Reg. No./Substance:
0/Aflatoxins; 0/Carcinogens; 0/Pyrrolizidine Alkaloids; 0/Toxins, Biological; 1162-65-8/Aflatoxin B1; 26400-45-3/dehydroretronecine; 315-22-0/Monocrotaline

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