Document Detail


Sensitivity and specificity of proposed DSM-5 criteria for autism spectrum disorder in toddlers.
MedLine Citation:
PMID:  23543293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autism spectrum disorder (ASD) diagnosis is based on behavioral presentation; changes in conceptual models or defining behaviors may significantly impact diagnosis and uptake of ASD-specific interventions. The literature examining impact of DSM-5 criteria is equivocal. Toddlers may be especially vulnerable to the stringent requirements of impairment in all three social-communication symptoms and two restricted/repetitive symptoms. Receiver operating characteristic (ROC) curves identified optimal cutoffs for sums of ADOS and ADI-R criteria mapped to each criterion for 422 toddlers. The optimal modification of DSM-5 criteria (sensitivity = 0.93, specificity = 0.74) required meeting the ROC-determined cutoffs for 2/3 Domain A criteria and 1 point for 1/4 Domain B criteria. This modification will help insure that ASD is identified accurately in young children, facilitating ASD-specific early intervention.
Authors:
Marianne L Barton; Diana L Robins; Dasal Jashar; Laura Brennan; Deborah Fein
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  43     ISSN:  1573-3432     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-11     Completed Date:  2013-10-21     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1184-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child Development Disorders, Pervasive / diagnosis*
Child, Preschool
Diagnostic and Statistical Manual of Mental Disorders*
Early Intervention (Education)
Female
Humans
Infant
Male
Questionnaires
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
R01 HD039961/HD/NICHD NIH HHS; R01HD039961/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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