| Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure. | |
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MedLine Citation:
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PMID: 20202922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent advances in high-field (>or=7 T) MRI have made it possible to study the fine structure of the human brain at the level of fiber bundles and cortical layers. In particular, techniques aimed at detecting MRI resonance frequency shifts originating from local variation in magnetic susceptibility and other sources have greatly improved the visualization of these structures. A recent theoretical study [He X, Yablonskiy DA (2009) Proc Natl Acad Sci USA 106:13558-13563] suggests that MRI resonance frequency may report not only on tissue composition, but also on microscopic compartmentalization of susceptibility inclusions and their orientation relative to the magnetic field. The proposed sensitivity to tissue structure may greatly expand the information available with conventional MRI techniques. To investigate this possibility, we studied postmortem tissue samples from human corpus callosum with an experimental design that allowed separation of microstructural effects from confounding macrostructural effects. The results show that MRI resonance frequency does depend on microstructural orientation. Furthermore, the spatial distribution of the resonance frequency shift suggests an origin related to anisotropic susceptibility effects rather than microscopic compartmentalization. This anisotropy, which has been shown to depend on molecular ordering, may provide valuable information about tissue molecular structure. |
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Authors:
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Jongho Lee; Karin Shmueli; Masaki Fukunaga; Peter van Gelderen; Hellmut Merkle; Afonso C Silva; Jeff H Duyn |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-03-02 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-04-22 Revised Date: 2010-09-17 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 5130-5 Citation Subset: IM |
Affiliation:
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Advanced MRI Section and Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. jonghoyi@mail.nih.gov |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anisotropy Brain / anatomy & histology* Computer Simulation Female Humans Magnetic Resonance Imaging* |
| Comments/Corrections | |
Erratum In:
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Proc Natl Acad Sci U S A. 2010 May 4;107(18):8498 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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