Document Detail

Sensitivity of the Doppler rate of pressure rise to changes in the inotropic state: an experimental comparison with invasively obtained dP/dt.
MedLine Citation:
PMID:  11916605     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate the sensitivity of the rate of pressure rise obtained by Doppler to changes in the inotropic state by comparing it to simultaneous invasive measurements of dP/dt under different conditions of contractility. METHODS AND RESULTS: Mitral regurgitation was provoked in five pigs, and simultaneous measurements of dP/dt and the Doppler-estimated rate of pressure rise were made with a micro-manometer and with continuous-wave Doppler. Changes in the inotropic state were induced by drug infusion and by ischaemia. One hundred and twenty-seven simultaneous measurements were made with a correlation coefficient between the Doppler-estimated rate of pressure rise and dP/dt of 0.85 (P<0.001). Sensitivity to inotropic changes was estimated as the percentage change of each parameter in each condition of contractility, and showed that the Doppler-estimated rate of pressure rise had better sensitivity than dP/dt. CONCLUSION: The sensitivity of Doppler-estimated rate of pressure rise to changes in the inotropic state is greater than that of dP/dt. The correlation between the rate of pressure rise obtained by Doppler and dP/dt is maintained even in extreme conditions of contractility. Therefore, the rate of pressure rise can be considered a good parameter to assess linear changes of contractility.
A García-Lledó; J L Moya; J Balaguer; E Asín
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  1     ISSN:  1525-2167     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2002-03-27     Completed Date:  2002-05-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-6     Citation Subset:  IM    
Department of Cardiology, General Hospital of Guadalajara, Spain.
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MeSH Terms
Blood Pressure / physiology*
Disease Models, Animal
Echocardiography, Doppler, Color*
Heart Atria / physiopathology,  ultrasonography
Mitral Valve Insufficiency / physiopathology,  ultrasonography
Models, Cardiovascular
Models, Theoretical
Multivariate Analysis
Myocardial Contraction / physiology*
Sensitivity and Specificity
Statistics as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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