Document Detail


Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): urinary 1-hydroxyprene glucuronide in relation to smoking and low ambient levels of exposure.
MedLine Citation:
PMID:  16908438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study was conducted in a Chinese population with occupational or environmental exposures to polycyclic aromatic hydrocarbons (PAHs). A total of 106 subjects were recruited from coke-oven workers (workers), residents in a metropolitan area (residents) and suburban gardeners (gardeners). All subjects were monitored twice for their personal exposures to PAHs. The biological samples were collected for measurements of 1-hydroxypyrene (1-OHP) and cotinine in urine. The geometric means of personal exposure levels of pyrene, benz(a)anthracene (BaA) and benzo(a)pyrene (BaP) in workers were 1.470, 0.978 and 0.805 microg m-3, respectively. The corresponding levels in residents were 0.050, 0.034 and 0.025 microg m-3; and those in gardeners were 0.011, 0.020 and 0.008 microg m-3, respectively. The conjugate of 1-OHP with glucuronide (1-OHP-G) is the predominant form of pyrene metabolite in urine and it showed strong associations with exposures not only to pyrene, but also to BaA, BaP and total PAHs. Most importantly, a significant difference in 1-OHP-G was even detected between the subgroups with exposures to BaP at < 0.010 and > 0.010 but < 0.020 microg m-3, suggesting that 1-OHP-G is a good marker that can be used for the risk assessment of BaP exposure at levels currently encountered in ambient air. Furthermore, multiple regression analyses of 1-OHP-G on PAHs exposure indicated that cigarette smoke was a major confounding factor and should be considered and adjusted for while using 1-OHP to estimate PAHs exposure.
Authors:
Y Hu; Z Zhou; X Xue; X Li; J Fu; B Cohen; A A Melikian; M Desai; M -S Tang; X Huang; N Roy; J Sun; P Nan; Q Qu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  11     ISSN:  1354-750X     ISO Abbreviation:  Biomarkers     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-08-15     Completed Date:  2006-12-22     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  306-18     Citation Subset:  IM    
Affiliation:
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA.
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants
Benz(a)Anthracenes / analysis
Benzo(a)pyrene / analysis
Biological Markers / chemistry*
Coke
Environmental Exposure
Female
Glucuronates / urine*
Glucuronides / urine*
Humans
Male
Occupational Exposure
Polycyclic Hydrocarbons, Aromatic / analysis*,  chemistry
Pyrenes / analysis
Risk Assessment
Smoking*
Grant Support
ID/Acronym/Agency:
ES00260/ES/NIEHS NIH HHS; R21 OH07632/OH/NIOSH CDC HHS
Chemical
Reg. No./Substance:
0/1-hydroxypyrene-glucuronide; 0/Air Pollutants; 0/Benz(a)Anthracenes; 0/Biological Markers; 0/Coke; 0/Glucuronates; 0/Glucuronides; 0/Polycyclic Hydrocarbons, Aromatic; 0/Pyrenes; 129-00-0/pyrene; 50-32-8/Benzo(a)pyrene; 56-55-3/benz(a)anthracene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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