| Sensitive assay for cocaine and benzoylecgonine using solid-phase extraction and gas chromatography. | |
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MedLine Citation:
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PMID: 7952114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An improved method for the simultaneous determination of cocaine and benzoylecgonine by means of gas chromatography with nitrogen-phosphorus detection is described. Following a solid-phase extraction and derivatization of benzoylecgonine to its butyl ester, chromatography was performed using a capillary column. The n-propylester of benzoylecgonine served as the internal standard. The assay was linear from 4 to 2000 ng/ml for both cocaine and benzoylecgonine, with a good precision over this concentration range. This method may be particularly useful for small volume samples since it requires only 250 microliters of plasma for analysis of both cocaine and benzoylecgonine. |
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Authors:
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L Virag; S Jamdar; C R Chao; H O Morishima |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of chromatography. B, Biomedical applications Volume: 658 ISSN: 1572-6495 ISO Abbreviation: J. Chromatogr. B, Biomed. Appl. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-12-28 Completed Date: 1994-12-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421796 Medline TA: J Chromatogr B Biomed Appl Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 135-41 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, College of Physicians & Surgeons, Columbia University, New York, NY 10032. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Gas
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methods*,
statistics & numerical data Cocaine / analogs & derivatives*, blood* Humans Hydrogen-Ion Concentration Microchemistry Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA 06648/DA/NIDA NIH HHS; R01 DA 07588/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 519-09-5/benzoylecgonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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