Document Detail

Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels.
MedLine Citation:
PMID:  19345226     Owner:  NLM     Status:  MEDLINE    
Despite the central physiological importance of cardiovascular mechanotransduction, the molecular identities of the sensors and the signaling pathways have long remained elusive. Indeed, how pressure is transduced into cellular excitation has only recently started to emerge. In both arterial and cardiac myocytes, the diacylglycerol-sensitive canonical transient receptor potential (TRPC) subunits are proposed to underlie the stretch-activated depolarizing cation channels. An indirect mechanism of activation through a ligand-independent conformational switch of Gq-coupled receptors by mechanical stress is invoked. Such a mechanism involving the angiotensin type 1 receptor and TRPC6 is proposed to trigger the arterial myogenic response to intraluminal pressure. TRPC6 is also involved in load-induced cardiac hypertrophy. In this review, we will focus on the molecular basis of pressure sensing in the cardiovascular system and associated disease states.
Reza Sharif-Naeini; Joost H A Folgering; Delphine Bichet; Fabrice Duprat; Patrick Delmas; Amanda Patel; Eric Honor?
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-04-01
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  48     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Inc. All rights reserved.
IPMC-CNRS, 660 route des Lucioles, Universit? de Nice Sophia Antipolis, 06560 Valbonne, France.
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MeSH Terms
Cardiomegaly / metabolism,  physiopathology
Cardiovascular System / metabolism*
Diglycerides / metabolism
Mechanoreceptors / chemistry,  metabolism*
Mechanotransduction, Cellular / physiology
Models, Biological
TRPC Cation Channels / chemistry,  metabolism*
Reg. No./Substance:
0/1,2-diacylglycerol; 0/Diglycerides; 0/TRPC Cation Channels

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