Document Detail


Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila.
MedLine Citation:
PMID:  24485457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The brain is the central organizer of food intake, matching the quality and quantity of the food sources with organismal needs. To ensure appropriate amino acid balance, many species reject a diet lacking one or several essential amino acids (EAAs) and seek out a better food source. Here, we show that, in Drosophila larvae, this behavior relies on innate sensing of amino acids in dopaminergic (DA) neurons of the brain. We demonstrate that the amino acid sensor GCN2 acts upstream of GABA signaling in DA neurons to promote avoidance of the EAA-deficient diet. Using real-time calcium imaging in larval brains, we show that amino acid imbalance induces a rapid and reversible activation of three DA neurons that are necessary and sufficient for food rejection. Taken together, these data identify a central amino-acid-sensing mechanism operating in specific DA neurons and controlling food intake.
Authors:
Marianne Bjordal; Nathalie Arquier; Julie Kniazeff; Jean Philippe Pin; Pierre Léopold
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  156     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-02-03     Completed Date:  2014-04-23     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  510-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids, Essential / metabolism*
Animals
Brain / cytology,  metabolism
Drosophila Proteins / metabolism
Drosophila melanogaster / physiology*
Eating
Neurons / metabolism*
Protein Kinases / metabolism
gamma-Aminobutyric Acid / metabolism
Chemical
Reg. No./Substance:
0/Amino Acids, Essential; 0/Drosophila Proteins; 56-12-2/gamma-Aminobutyric Acid; EC 2.7.-/GCN2 protein, Drosophila; EC 2.7.-/Protein Kinases
Comments/Corrections
Comment In:
Curr Biol. 2014 Mar 31;24(7):R278-80   [PMID:  24698377 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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