Document Detail


Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors.
MedLine Citation:
PMID:  19726694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The arterial baroreceptor is critically involved in the autonomic regulation of homoeostasis. The transient receptor potential vanilloid 1 (TRPV1) receptor is expressed on both somatic and visceral sensory neurons. Here, we examined the TRPV1 innervation of baroreceptive pathways and its functional significance in the baroreflex. Resiniferatoxin (RTX), an ultrapotent analog of capsaicin, was used to ablate TRPV1-expressing afferent neurons and fibers in adult rats. Immunofluorescence labeling revealed that TRPV1 immunoreactivity was present on nerve fibers and terminals in the adventitia of the ascending aorta and aortic arch, the nodose ganglion neurons, and afferent fibers in the solitary tract of the brainstem. RTX treatment eliminated TRPV1 immunoreactivities in the aorta, nodose ganglion, and solitary tract. Renal sympathetic nerve activity, blood pressure, and heart rate were recorded in anesthetized rats. The baroreflex was triggered by lowering and raising blood pressure through intravenous infusion of sodium nitroprusside and phenylephrine, respectively. Inhibition of sympathetic nerve activity and heart rate by the phenylephrine-induced increase in blood pressure was largely impaired in RTX-treated rats. The maximum gain of the baroreflex function was significantly lower in RTX-treated than vehicle-treated rats. Furthermore, blocking of TRPV1 receptors significantly blunted the baroreflex and decreased the maximum gain of baroreflex function in the high blood pressure range. Our findings provide important new information that TRPV1 is expressed along the entire baroreceptive afferent pathway. TRPV1 receptors expressed on baroreceptive nerve endings can function as mechanoreceptors to detect the increase in blood pressure and maintain the homoeostasis.
Authors:
Hao Sun; De-Pei Li; Shao-Rui Chen; Walter N Hittelman; Hui-Lin Pan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-09-02
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  331     ISSN:  1521-0103     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-26     Completed Date:  2009-12-22     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  851-9     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Perioperative Medicine, the University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Afferent Pathways / drug effects,  metabolism,  physiology*
Animals
Baroreflex / drug effects,  physiology*
Blood Pressure / drug effects,  physiology*
Diterpenes / pharmacology
Heart Rate / drug effects,  physiology
Kidney / innervation
Male
Nerve Fibers / metabolism
Nodose Ganglion / metabolism
Pressoreceptors / metabolism,  physiology*
Rats
Rats, Sprague-Dawley
Sympathetic Nervous System / metabolism,  physiology
TRPV Cation Channels / agonists,  antagonists & inhibitors,  physiology*
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Grant Support
ID/Acronym/Agency:
HL77400/HL/NHLBI NIH HHS; NS45602/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Diterpenes; 0/TRPV Cation Channels; 0/Trpv1 protein, rat; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; A5O6P1UL4I/resiniferatoxin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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