Document Detail

Senile systemic amyloidosis: are regional differences real or do they reflect different diagnostic suspicion and use of techniques?
MedLine Citation:
PMID:  22620969     Owner:  NLM     Status:  In-Data-Review    
Amyloid deposits in the heart derived from transthyretin are commonly seen at autopsy in elderly patients. Massive deposition, causing senile systemic amyloidosis (SSA), is considered to be relatively uncommon and reported series suggest that SSA is considerably less common than amyloid light-chain (AL) amyloidosis. This article reviews the autopsy prevalence of transthyretin-derived cardiac amyloid, addresses whether there is definitive evidence for regional or ethnic differences and argues that the reported prevalence of SSA significantly underrepresents the true prevalence of the disease which may be as common, or commoner, than AL amyloidosis.
Rodney H Falk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis     Volume:  19 Suppl 1     ISSN:  1744-2818     ISO Abbreviation:  Amyloid     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433802     Medline TA:  Amyloid     Country:  England    
Other Details:
Languages:  eng     Pagination:  68-70     Citation Subset:  IM    
Brigham and Women's Hospital Cardiac Amyloidosis Program, Harvard Medical School , Boston, MA , USA.
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