Document Detail


Senile dementia and healthy aging: a longitudinal CT study.
MedLine Citation:
PMID:  2006279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Volumetric indexes of cerebral atrophy obtained by using computed tomography (CT) were measured longitudinally in patients with senile dementia of the Alzheimer type (SDAT) and in healthy elderly control subjects. Measurements were made three times over a 51-month period. Of the original 44 patients with SDAT, five were available for CT examination at the last time of assessment (51 months); in contrast, 41 of the original 58 control subjects were still available for study at 51 months. As a group, scans of SDAT subjects showed greater atrophy than those of control subjects in all volumetric indexes at each time of testing and demonstrated greater progression of atrophy during the study period. However, the overlap of indexes between the patients with SDAT and the control subjects indicates that CT data cannot be used alone to predict the presence or progression of dementia in individual cases.
Authors:
F J Wippold; M H Gado; J C Morris; J M Duchek; E A Grant
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  179     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-04-23     Completed Date:  1991-04-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  AIM; IM    
Affiliation:
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging*
Alzheimer Disease / pathology,  radiography*
Atrophy
Brain / pathology,  radiography*
Humans
Longitudinal Studies
Grant Support
ID/Acronym/Agency:
AG03991/AG/NIA NIH HHS; AG05681/AG/NIA NIH HHS; MH31054/MH/NIMH NIH HHS

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