| Senescing cells share common features with dedifferentiating cells. | |
MedLine Citation:
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PMID: 20041737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dedifferentiation signifies the capacity of somatic cells to acquire stem cell-like properties. This process can be induced during normal development and as a response to various stimuli, such as pathogen infection and wounding. Dedifferentiation also characterizes the transition of differentiated leaf cells into protoplasts (plant cells devoid of cell walls), a transition accompanied by widespread chromatin decondensation. Transcriptome profiling of dedifferentiating protoplast cells revealed striking similarities with senescing cells; both display a large increase in the expression of genes of specific transcription factor (TF) families, including ANAC, WRKY, bZIP, and C2H2. Further analysis showed that leaves induced to senesce by exposure to dark display characteristic features of dedifferentiating cells, including chromatin decondensation, disruption of the nucleolus, and condensation of rRNA genes. Considering that premature senescence can be induced by various stress conditions both in plant and animal cells, our results suggest that the response of plant and also animal cells to certain stresses converges on cellular dedifferentiation whereby cells first acquire stem cell-like state prior to acquisition of a new cell fate (e.g., reentry into the cell cycle or death). |
Authors:
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Meytal Damri; Gila Granot; Hagit Ben-Meir; Yigal Avivi; Inbar Plaschkes; Vered Chalifa-Caspi; Marina Wolfson; Vadim Fraifeld; Gideon Grafi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rejuvenation research Volume: 12 ISSN: 1557-8577 ISO Abbreviation: Rejuvenation Res Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-31 Completed Date: 2010-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 435-43 Citation Subset: IM |
Affiliation:
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French Associates Institute for Agriculture and Biotechnology of Drylands, Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Beer-Sheva, Israel and Midreshet Ben-Gurion, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arabidopsis
/
cytology*,
enzymology,
genetics Cell Aging / physiology* Cell Dedifferentiation / physiology* Cell Nucleolus / metabolism DNA, Ribosomal / genetics Darkness Gene Expression Profiling Gene Expression Regulation, Plant Mitogen-Activated Protein Kinases / metabolism Plant Leaves / cytology, enzymology, genetics Protoplasts / cytology, enzymology Transcription Factors / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/DNA, Ribosomal; 0/Transcription Factors; EC 2.7.11.24/Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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