| Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells. | |
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MedLine Citation:
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PMID: 19826058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies on human fibroblasts have led to viewing senescence as a barrier against tumorigenesis. Using keratinocytes, we show here that partially transformed and tumorigenic cells systematically and spontaneously emerge from senescent cultures. We show that these emerging cells are generated from senescent cells, which are still competent for replication, by an unusual budding-mitosis mechanism. We further present data implicating reactive oxygen species that accumulate during senescence as a potential mutagenic motor of this post-senescence emergence. We conclude that senescence and its associated oxidative stress could be a tumor-promoting state for epithelial cells, potentially explaining why the incidence of carcinogenesis dramatically increases with advanced age. |
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Authors:
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Karo Gosselin; Sébastien Martien; Albin Pourtier; Chantal Vercamer; Peter Ostoich; Luc Morat; Laure Sabatier; Laurence Duprez; Claire T'kint de Roodenbeke; Eric Gilson; Nicolas Malaquin; Nicolas Wernert; Predrag Slijepcevic; Marjan Ashtari; Fazia Chelli; Emeric Deruy; Bernard Vandenbunder; Yvan De Launoit; Corinne Abbadie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-13 |
Journal Detail:
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Title: Cancer research Volume: 69 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-16 Completed Date: 2009-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 7917-25 Citation Subset: IM |
Affiliation:
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Université Lille Nord de France, CNRS, UMR8161, UDSL, Institut Pasteur de Lille, Lille, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae Adolescent Adult Alu Elements Blotting, Western Cell Aging* Cell Proliferation Cell Transformation, Neoplastic* Cells, Cultured Comet Assay DNA Damage* DNA Probes Epidermis / metabolism, pathology Female Fibroblasts / metabolism, pathology Fluorescent Antibody Technique Humans In Situ Hybridization Karyotyping Keratinocytes / metabolism, pathology Middle Aged Neoplasms / metabolism, pathology* Oxidative Stress* Reactive Oxygen Species / metabolism* Superoxide Dismutase / metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes; 0/Reactive Oxygen Species; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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