| Senescence-associated HSP60 expression in normal human skin fibroblasts. | |
| | |
MedLine Citation:
|
PMID: 15791579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Normal mammalian fibroblasts cultured in vitro undergo a limited number of divisions before entering a senescent phase in which they can be maintained for long periods but cannot be induced to divide. Senescent cells become unresponsive to growth-promoting signals and exhibit senescent cell morphology with flattened and enlarged cell shape. Several chaperones have a direct effect on cellular senescence. HSP60 has been largely studied in our laboratories and it has been associated with uncontrolled cell proliferation in tumor cells. Since senescence is firmly regulated during cell cycle progression, we wanted to investigate HSP60 protein level during cellular senescence. Our data show that HSP60 increases during the initial stage of senescence and that it is localized in cellular compartments, resembling mitochondria. An increase in HSP60 protein amount is associated with a cell cycle slow-down and it may have a role in cell cycle progression. |
| | |
Authors:
|
Valentina Di Felice; Nella Ardizzone; Vito Marcianò; Tommaso Bartolotta; Francesco Cappello; Felicia Farina; Giovanni Zummo |
Related Documents
:
|
12645879 - Origin of late-onset autoimmune disease. 19805069 - Cell surface-bound il-1alpha is an upstream regulator of the senescence-associated il-6... 14718559 - The transcriptome of prematurely aging yeast cells is similar to that of telomerase-def... 15479119 - Spontaneous cell transformation: karyoplasts derived from multinucleated cells produce ... 11248249 - Decreased antioxidant defense during replicative aging of the yeast saccharomyces cerev... 12083799 - Induction of senescence-like state and suppression of telomerase activity through inhib... 10704909 - Uptake of dehydroepiandrosterone-3-sulfate by isolated trophoblasts from human term pla... 72829 - Supravital staining of spermatozoa: relationship of eosin concentration to the percenta... 17696999 - Sopd acts cooperatively with sopb during salmonella enterica serovar typhimurium invasion. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Volume: 284 ISSN: 1552-4884 ISO Abbreviation: - Publication Date: 2005 May |
Date Detail:
|
Created Date: 2005-06-07 Completed Date: 2005-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101234285 Medline TA: Anat Rec A Discov Mol Cell Evol Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 446-53 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2005 Wiley-Liss, Inc. |
Affiliation:
|
Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana Emerico Luna, Università di Palermo, Palermo, Italy. vdfelice@inwind.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Markers
/
metabolism Cell Aging / physiology* Cell Cycle / physiology Cell Division Cells, Cultured Chaperonin 60 / metabolism* Fibroblasts / metabolism*, ultrastructure Fluorescent Antibody Technique, Direct Humans Immunoenzyme Techniques Male Microscopy, Electron, Scanning Vimentin / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Chaperonin 60; 0/Vimentin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunocytochemical localization of MAPKAPK-2 and Hsp25 in the rat temporomandibular joint.
Next Document: Evidence for frequency-dependent arterial damage in vibrated rat tails.