Document Detail


Senescence as a modulator of oral squamous cell carcinoma development.
MedLine Citation:
PMID:  21050803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Senescence of somatic cells in vitro can occur through the gradual erosion of the chromosomal telomeres following multiple rounds of cell division, or more acutely following cellular stresses connected with oncogene activation, tumour suppressor loss, ageing and migration. These various forms of senescence are associated with the activation of DNA damage checkpoints, the over-expression of p16(INK4A) and the secretion of cytokines, all of which are detected in pre-malignant lesions but muted upon malignant conversion. The various senescence signals are integrated by p16(INK4A) and p53 to produce the permanent cell cycle arrest associated with senescence. Both pRB/p16(INK4A) and p53 are dysfunctional in many cancers, including the most common type of oral cancer, squamous cell carcinoma (OSCC) and other evidence is accumulating in support of the idea that senescence acts as a barrier to tumour development and/or progression. However, senescence of the non-epithelial component of developing human tumours has been shown to enhance growth and invasion of the pre-malignant epithelial component and so senescence may well enhance cancer as well as suppress it depending on the context.
Authors:
E Kenneth Parkinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-11-02
Journal Detail:
Title:  Oral oncology     Volume:  46     ISSN:  1879-0593     ISO Abbreviation:  Oral Oncol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-04-14     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  840-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / genetics,  pathology*
Cell Aging / genetics,  physiology*
Cell Line, Tumor
Female
Genes, p16 / physiology*
Humans
Male
Mouth Neoplasms / genetics,  pathology*
Tumor Suppressor Protein p53 / genetics,  physiology*
Grant Support
ID/Acronym/Agency:
//Biotechnology and Biological Sciences Research Council
Chemical
Reg. No./Substance:
0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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