Document Detail

Senescence and apoptosis in yeast mother cell-specific aging and in higher cells: a short review.
MedLine Citation:
PMID:  18342634     Owner:  NLM     Status:  MEDLINE    
It is our intention to give the reader a short overview of the relationship between apoptosis and senescence in yeast mother cell-specific aging. We are studying yeast as an aging model because we want to learn something of the basic biology of senescence and apoptosis even from a unicellular eukaryotic model system, using its unrivalled ease of genetic analysis. Consequently, we will discuss also some aspects of apoptosis in metazoa and the relevance of yeast apoptosis and aging research for cellular (Hayflick type) and organismic aging of multicellular higher organisms. In particular, we will discuss the occurrence and relevance of apoptotic phenotypes for the aging process. We want to ask the question whether apoptosis (or parts of the apoptotic process) are a possible cause of aging or vice versa and want to investigate the role of the cellular stress response system in both of these processes. Studying the current literature, it appears that little is known for sure in this field and our review will therefore be, for a large part, more like a memorandum or a program for future research.
Peter Laun; Gino Heeren; Mark Rinnerthaler; Raphaela Rid; Sonja Kössler; Lore Koller; Michael Breitenbach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-03-04
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1783     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-08-13     Revised Date:  2011-04-06    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1328-34     Citation Subset:  IM    
Department of Cell Biology, Division of Genetics, University of Salzburg, Salzburg, Austria.
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MeSH Terms
Aging / genetics,  physiology*
Apoptosis / genetics,  physiology*
Caenorhabditis elegans / genetics,  physiology
Cell Aging / genetics,  physiology*
Saccharomyces cerevisiae / cytology*,  genetics,  physiology
Yeasts / cytology*,  genetics,  physiology
Grant Support
S 9302-B18//Austrian Science Fund FWF

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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