| Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity. | |
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MedLine Citation:
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PMID: 20421239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the change in lipoprotein metabolism with aging, we analyzed the lipid and protein compositions of individual lipoprotein fractions. Healthy and nonobese elderly participants (elderly group, n = 26) had a serum lipid profile within the normal range, although slightly higher than in young participants (control group, n = 18). However, the elderly group had a twofold higher serum uric acid level and triglyceride (TG):high-density lipoprotein cholesterol ratio. The elderly group had less antioxidant ability and elevated TG content in high-density lipoprotein (HDL) with enhanced cholesteryl ester transfer activity. An elevated level of advanced glycated end products in lipoproteins and fragmentation of apoA-I were present in the elderly group, with detected lower apoA-I level and more multimerized apoA-I in HDL. The protein levels of apoA-I, apoC-III, and serum amyloid A in lipoprotein-deficient serum were increased in the elderly group. |
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Authors:
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Ki-Hoon Park; Dong-Gu Shin; Jae-Ryong Kim; Kyung-Hyun Cho |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-26 |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 65 ISSN: 1758-535X ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 600-10 Citation Subset: AIM; IM |
Affiliation:
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School of Biotechnology, Yeungnam University, Gyeongsan 712-749, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / blood* Antioxidants / metabolism Apolipoprotein A-I / blood*, chemistry*, isolation & purification, metabolism Apolipoprotein C-III / blood Aryldialkylphosphatase / blood Cholesterol Ester Transfer Proteins / blood* Cholesterol, HDL / blood Glycosylation End Products, Advanced / blood* Humans Lipids / blood, chemistry Lipoproteins / blood Lipoproteins, HDL / blood*, chemistry* Male Particle Size Protein Isoforms / blood Reference Values Serum Amyloid A Protein / metabolism Triglycerides / blood Uric Acid / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Apolipoprotein A-I; 0/Apolipoprotein C-III; 0/Cholesterol Ester Transfer Proteins; 0/Cholesterol, HDL; 0/Glycosylation End Products, Advanced; 0/Lipids; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Protein Isoforms; 0/Serum Amyloid A Protein; 0/Triglycerides; 69-93-2/Uric Acid; EC 3.1.8.1/Aryldialkylphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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