Document Detail

Semisynthetic penicillins. A structure - activity study of a new series of acyl amino acid - pyridone and pyrimidone amoxicillin analogs.
MedLine Citation:
PMID:  7287589     Owner:  NLM     Status:  MEDLINE    
The synthesis and biological activities of a series of 12 new semisynthetic penicillins is described. These compounds consisted of acylated amino acid analogs of 6-substituted-1,2-dihydro-2-oxonicotinic acid and 2-substituted-3,4-dihydro-4-oxo-5-pyrimidinecarboxylic acid attached to amoxicillin. The effect of the amino acid substituent, chirality of amino acid and acyl function on biological properties is discussed.
T H Haskell; P W Woo; E D Nicolaides; M P Hutt; G G Huang; J P Sanchez; D DeJohn; C L Heifetz; U Krolls; E Lunney; T F Mich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  34     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  862-8     Citation Subset:  IM    
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MeSH Terms
Amoxicillin / analogs & derivatives*,  pharmacology
Bacteria / drug effects
Microbial Sensitivity Tests
Structure-Activity Relationship
Reg. No./Substance:

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