| Semisynthetic penicillins. A structure - activity study of a new series of acyl amino acid - pyridone and pyrimidone amoxicillin analogs. | |
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MedLine Citation:
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PMID: 7287589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis and biological activities of a series of 12 new semisynthetic penicillins is described. These compounds consisted of acylated amino acid analogs of 6-substituted-1,2-dihydro-2-oxonicotinic acid and 2-substituted-3,4-dihydro-4-oxo-5-pyrimidinecarboxylic acid attached to amoxicillin. The effect of the amino acid substituent, chirality of amino acid and acyl function on biological properties is discussed. |
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Authors:
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T H Haskell; P W Woo; E D Nicolaides; M P Hutt; G G Huang; J P Sanchez; D DeJohn; C L Heifetz; U Krolls; E Lunney; T F Mich |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antibiotics Volume: 34 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 1981 Jul |
Date Detail:
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Created Date: 1981-12-21 Completed Date: 1981-12-21 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 862-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amoxicillin
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analogs & derivatives*,
pharmacology Bacteria / drug effects Microbial Sensitivity Tests Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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26787-78-0/Amoxicillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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