| Semisynthetic beta-Lactam antibiotics. II. Penicillins from alpha-hydrazinoarylacetic acids. | |
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MedLine Citation:
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PMID: 885795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A number of penicillins (2) have been synthesized from the alpha-hydrazinoarylacetic acids (4) via the activated chloride hydrochlorides (5) or via the mixed anhydride of the corresponding N2-benzyloxycarbonyl derivatives (6). The penicillins, 2b, e, j, show good activity against gram-positive and gram-negative bacteria and enhanced penicillinase resistance in comparison with ampicillin. |
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Authors:
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G LiBassi; R Monguzzi; R Broggi; G Broccali; C Carpi; G Pifferi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antibiotics Volume: 30 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-09-22 Completed Date: 1977-09-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 376-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids Bacteria / drug effects Chemical Phenomena Chemistry Drug Stability Hydrazines Microbial Sensitivity Tests Penicillinase / metabolism Penicillins / analysis, chemical synthesis*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Hydrazines; 0/Penicillins; EC 3.5.2.-/Penicillinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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