| Semiquinones derived from anthraquinone-containing antitumor drugs can partition into phosphatidylcholine bilayers. | |
| | |
MedLine Citation:
|
PMID: 2166575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Semiquinones derived from anthraquinone-containing antitumor drugs (doxorubicin, daunorubicin and 4'-epidoxorubicin) were generated by the hypoxanthine/xanthine oxidase system in argon-saturated phosphate buffer (pH 7.4) in the presence of egg-yolk phosphatidylcholine multilamellar vesicles (MLVs) containing 1 mol% of a doxylstearic acid (DSA) isomer. The destruction of the electron spin resonance signal corresponding to 5-, 12- and 15-DSA included in the MLVs follows pseudo-first-order kinetics. Higher rates of destruction are obtained for the 12-DSA isomer which indicates that these semiquinones can localize preferentially about the depth of the 12th position of stearic acid in membranes. It is demonstrated that DSA destruction is due to a reversible reduction of DSA to the hydroxylamine species. This work shows that anthracycline semiquinones can partition into phosphatidylcholine bilayers under anoxic conditions which may imply another pathway in their cytotoxic action. |
| | |
Authors:
|
A E Alegría; M S Rodríguez; J Hernández |
Related Documents
:
|
16899265 - Digestive properties of the venom of the australian coastal taipan, oxyuranus scutellat... 7284425 - Studies on cyclopropane fatty acid synthesis. correlation between the state of reductio... 1829425 - Regulation of biosynthesis of l-amino acid oxidase by neurospora crassa. 6348285 - Inhibitors of glycolic acid oxidase. 4-substituted 2,4-dioxobutanoic acid derivatives. 10222005 - Quantification of the major urinary metabolite of 15-f2t-isoprostane (8-iso-pgf2alpha) ... 3914305 - Nutrition in acute renal failure. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Biochimica et biophysica acta Volume: 1035 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1990 Jul |
Date Detail:
|
Created Date: 1990-09-20 Completed Date: 1990-09-20 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 51-5 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, University of Puerto Rico, Humacao 00661. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anthraquinones
/
metabolism* Antineoplastic Agents / metabolism* Benzoquinones* Cell Membrane / analysis Electron Spin Resonance Spectroscopy Kinetics Lipid Bilayers / metabolism* Phosphatidylcholines* Quinones / analysis* Stearic Acids / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
RR08216/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anthraquinones; 0/Antineoplastic Agents; 0/Benzoquinones; 0/Lipid Bilayers; 0/Phosphatidylcholines; 0/Quinones; 0/Stearic Acids; 3225-29-4/semiquinone radicals; 57-11-4/stearic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chemical reactivity of potassium permanganate and diethyl pyrocarbonate with B DNA: specific reactiv...
Next Document: Properties of the ATPase activity associated with peroxisome-enriched fractions from rat liver: comp...