| Semiquantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging measurements predict radiation response in cervix cancer. | |
| | |
MedLine Citation:
|
PMID: 19019563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate semiquantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measurements in predicting the response to radiotherapy in cervix cancer. METHODS AND MATERIALS: Patients with cervix cancer treated radically with chemoradiotherapy had DCE-MRI at three time points: before starting treatment, after 2 weeks of radiotherapy, and in the 5th week of radiotherapy. Semiquantitative measurements obtained from the signal intensity vs. time plots included arrival time of contrast, the slope and maximum slope of contrast uptake, time for peak enhancement, and the contrast enhancement ratio (CER). Pharmacokinetic modeling with a modeled vascular input function was used for the quantitative measurements volume transfer constant (K(trans)), rate constant (k(ep)), fraction plasma volume (fPV), and the initial area under gadolinium-time curve. The correlation of these measurements at each of the three time points with radiologic tumor response was investigated. RESULTS: Thirteen patients had a total of 38 scans. There was no correlation between the DCE-MRI measurements and the corresponding tumor volumes. A statistically significant correlation with percentage tumor regression was shown with the pretreatment DCE-MRI semiquantitative parameters of peak time (p = 0.046), slope (p = 0.025), maximum slope (p = 0.046), and CER (p = 0.025) and the quantitative parameters K(trans) (p = 0.043) and k(ep) (p = 0.022). Second and third scan measurements did not show any correlation. CONCLUSIONS: This is the first study to show that pretreatment DCE-MRI quantitative parameters predict the radiation response in cervix cancer. These measurements may allow a more meaningful comparison of DCE-MRI studies from different centers. |
| | |
Authors:
|
Mark A Zahra; Li Tee Tan; Andrew N Priest; Martin J Graves; Mark Arends; Robin A F Crawford; James D Brenton; David J Lomas; Evis Sala |
Related Documents
:
|
8011393 - Ct demonstration of prostatic zonal anatomy during dynamic contrast infusion. 2367663 - Rheumatoid arthritis: evaluation of hypervascular and fibrous pannus with dynamic mr im... 15707793 - The mr detection of neuronal depolarization during 3-hz spike-and-wave complexes in gen... |
Publication Detail:
|
Type: Journal Article Date: 2008-11-18 |
Journal Detail:
|
Title: International journal of radiation oncology, biology, physics Volume: 74 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-06-01 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
|
Languages: eng Pagination: 766-73 Citation Subset: IM |
Affiliation:
|
Edinburgh Cancer Centre, Western General Hospital, Edinburgh, United Kingdom. zahramark@doctors.org.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
drug therapy,
pathology,
radiotherapy* Adult Aged Aged, 80 and over Antineoplastic Agents / administration & dosage Carcinoma, Squamous Cell / drug therapy, pathology, radiotherapy* Cisplatin / administration & dosage Contrast Media / diagnostic use Female Gadolinium Humans Image Enhancement / methods Magnetic Resonance Imaging / methods* Middle Aged Radiation-Sensitizing Agents / administration & dosage Radiotherapy Dosage Uterine Cervical Neoplasms / drug therapy, pathology, radiotherapy* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 0/Contrast Media; 0/Radiation-Sensitizing Agents; 15663-27-1/Cisplatin; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A dosimetric comparison of proton and intensity-modulated photon radiotherapy for pediatric parameni...
Next Document: Usefulness of diffusion-weighted imaging in the localization of prostate cancer.