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Semiquantitative measurement of pulmonary hilar gallium-67 uptake using single photon emission computed tomography/computed tomography for the diagnosis of autoimmune pancreatitis.
MedLine Citation:
PMID:  21191738     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE: We ascertained the difference in the level of pulmonary hilar (PH) gallium-67 (Ga-67) uptake in autoimmune pancreatitis (AIP) patients between the active (before corticosteroid therapy) and remittent (after 4 weeks of corticosteroid therapy) phases using a semiquantitative measurement method based on single photon emission computed tomography (SPECT) with integrated low-dose computed tomography (CT).
MATERIALS AND METHODS: Ga-67 planar scans and SPECT were performed in 11 AIP patients before and after 4 weeks of corticosteroid therapy. A region of interest (ROI) was drawn over the bilateral pulmonary hilum and the liver, and average counts of the pulmonary hilum and liver were calculated. The average counts of the pulmonary hilum divided by those of the liver gave the pulmonary hilum/liver ratio (H/L).
RESULTS: A significant difference was observed in the H/L between active and remittent phases. H/L in the active phase was 1.03±0.32 and that in the remittent phase was 0.58±0.25 (t-test, P=0.0016).
CONCLUSIONS: PH Ga-67 uptake in patients with active AIP was semiquantitatively higher than that in those with remittent AIP. Hence, this may be a useful finding for an early diagnosis, estimating the effectiveness of corticosteroid therapy, and following up patients with this disease.
Authors:
Mitsuhiro Momose; Masumi Kadoya; Kesato Yano; Tadashi Miyasaka; Yasunari Fujinaga; Tsuyoshi Matsushita; Shin Yanagisawa; Hideaki Hamano; Shigeyuki Kawa
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Publication Detail:
Type:  Journal Article     Date:  2010-12-30
Journal Detail:
Title:  Japanese journal of radiology     Volume:  28     ISSN:  1867-108X     ISO Abbreviation:  Jpn J Radiol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101490689     Medline TA:  Jpn J Radiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  733-9     Citation Subset:  IM    
Affiliation:
Department of Radiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan. momosemi@shinshu-u.ac.jp
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